md-medicaldata

Authors

 

Bojana Đenadija1, Miroslav Mitrović1, Valerija Munteanu2, Ivona Martinović3, Dušan Lalošević<sup>4

1</sup>Odeljenje pedijatrije, Opšta bolnica „Dr Radivoj Simonović“, Sombor, Vojvođanska 75, 25000 Sombor
²Centar za radiologiju, Univerzitetski klinički centar Vojvodine, Novi Sad, Hajduk Veljkova 1, 21000 Novi Sad
³Centar za mikrobiologiju, Institut za javno zdravlje Vojvodine, Futoška 121, 21000 Novi Sad
⁴Medicinski fakultet, Univerzitet u Novom Sadu, Hajduk Veljkova 3, 21000 Novi Sad

 

UDK: 616.995.132-053.2

The paper was received / Rad primljen: 20.07.2024.

Accepted / Rad prihvaćen: 01.08.2024.

 

Correspondence to:

Prof. dr Dušan Lalošević
Medicinski fakultet
Hajduk Veljkova 3
21000 Novi Sad
e-mail: dusan.lalosevic@mf.uns.ac.rs

 

 

Sažetak

 

 

Toksokarijaza kod deteta sa hipereozinofilijom, plućnim simptomima i pozitivnim radiološkim nalazom dokazana je nađenim visokim titrom antitela u dve metode, ELISA i indirektnim imunofluorescentnim testom. Na rengenskom snimku pluća nađena su brojna mrljasta zasenčenja parenhima. Nakon terapije albendazolom, 15mg/kg tokom 28 dana, stanje se znatno popravilo, bez kliničkih simptoma i sa laboratorijski dokazanom regresijom infekcije. Nakon četiri meseca eozinofilija je sa 44% spala na 10%, kontrolni snimak pluća je postao normalan, titar antitela u ELISA testu ostao je jednako visok, ali se titar imunofluorescentnih antitela smanjio oko deset puta. Poredjenje ELISA i indirektnog imunofluorescentnog testa pokazalo je da imunofluorescentni test bolje prati rezoluciju kliničke slike posle primenjene terapije.

 

Ključne reči:

Toksokarijaza, plućni infiltrati, albendazol, imunofluorescentni test.

 

 

 

Abstract

 

Toxocariasis in a child with hypereosinophilia, pulmonary symptoms and a positive radiological finding was proven by the high titer of antibodies found with two methods, ELISA and indirect immunofluorescence test. On the X-ray of the lungs, numerous patchy shadows of the parenchyma were found. After treatment with albendazole, 15 mg/kg for 28 days, the condition improved considerably, without clinical symptoms and with laboratory-proven regression of the infection. After four months, the eosinophilia dropped from 44% to 10%, the control lung scan became normal, the antibody titer in the ELISA test remained as high, but the immunofluorescent antibody titer decreased about ten times. The correlation of ELISA and indirect immunofluorescence test showed that the immunofluorescence test better follows the resolution of the clinical picture after the applied therapy.

 

Key words:

Toxocariasis, pulmonary infiltrates, albendazole, immunofluorescence test.

 

 

 

 

References:

1. Lalošević D, Lalošević V. Toksokarijaza-larva migrans kod čoveka i životinja. Zadužbina Andrejević, Beograd, 2008.
2. Pavlović I, Jovičić D, Petrović N, Vitas A, Ilić Ž, Aleksić S. 2014. Control of parasitic contamination of green areas in urban environment – Belgrade experience. Archiv Tech Sci. 1(11):73–76.
3. Raicević JG, Pavlović I, Galonja-Coghill TA. Canine intestinal parasites as a potential source of soil contamination in the public areas of Krusevac, Serbia. Journal of infection in developing countries. 2021;15(1):147-54.
4. Ristić M, Pavlović I, Tasić NM, Babić R, Kocić B. Epidemiological importance of green areas and public places contaminated with canine feces in urban environmental conditions. Acta Medica Medianae. 2017;56(3).
5. Považan Đ, Đurić M, Uzurov-Dinić V, Lalošević D, Lalošević V, Sečen S, Považan A. Adult human case of toxocariasis with pulmonary migratory infiltrate and eosinophilia. Vojnosanitetski pregled. 2011;68(10):881-5.
6. Milić R, Šarac S, Nikolajević S, Rusović S, Šarac M. Pulmonary toxocariasis. Respiratio 2015; 5 (1-2): 211-214.
7. Lalošević D. Mogućnost upotrebe larvi Toxocara canis kao antigena za test indirektne imunofluorescencije. Magistarski rad, Vojnomedicinska akademija Beograd, 1990.
8. Lalošević D. Ekologija i epidemiologija toksokarijaze u Novom Sadu. Doktorska disertacija, Vojnomedicinska akademija Beograd, 1999.
9. Mijatović D, Ćalasan N, Simin V, Lalošević D. Nadzor pacijenta sa toksokarijazom – Prikaz slučaja. MD-Medical Data 2015;7(4): 327-329.
10. Lalošević D, Lalošević V, Uzurov V, Rončević N, Gebauer E, Sekulić S, Kuzmanović S, Momirovska A. Izbor terapijskog protokola i praćenje efekta terapije albendazolom pacijenata sa toksokarijazom. MD-Medical Data 2009;1(3): 65-68.
11. Todorović S. Neurotoxocariasas: A Case Report with Correlation of Clinical Symptoms and Radiographic Imaging. Acta medica Medianae. 2020;59(4).
12. Lalošević D. Aktivna toksokarijaza i hiperaktivno dete. MD-Medical Data 2019;11(3-4): 189-190.
13. Lalošević D, Oros A, Lalošević V, Knežević K, Knežević S, Božić K, Vlajković K, Gebauer E. Pojava visceralne i okularne kliničke slike toksokarijaze kod šestogodišnjeg dečaka. Med Pregl. 2001;54 Suppl 1:51-3.
    

PDF: 08-Đenadija B. et al MD-Medical Data 2024;16(2) 117-119.pdf