md-medicaldata

Authors

 

Tamara Živić^1,2, Eliana Garalejić², Strahinja Križak², Aleksa Radivojević², Artur Bjelica<sup>1,3

1</sup>Medicinski fakultet Novi Sad, Univerzitet u Novom Sadu, Novi Sad, Srbija
²Specijalna bolnica za ginekologiju sa porodilištem „Jevremova“, Beograd, Srbija
³Klinika za ginekologiju i akušerstvo, Univerzitetski klinički centar Vojvodine, Novi Sad, Srbija/p>

 

UDK: 612.612.2

The paper was received / Rad primljen: 15.07.2024

Accepted / Rad prihvaćen: 18.07.2024.

 

Correspondence to:

Tamara Živić
Univerzitet u Novom Sadu, Medicinski fakultet;
Specijalna bolnica za ginekologiju sa porodilištem “Jevremova“ Medigroup, Beograd
tel.: 065 2333 781
e-mail: zivictamara175@gmail.com.rs

 

 

Sažetak

 

 

Prema podacima Svetske zdrastvene organizacije (WHO-SZO), stopa infertilnosti je u stalnom porastu. Ovo je naročito izraženo u kategoriji muškaraca mlađe životne dobi što je veoma važno, jer su kvalitet sperme i muški fertilitet bitni pokazatelji, ne samo reproduktivnog, već opšteg zdravlja organizma. Cilj ovog preglednog rada je da se utvrdi povezanost i značaj pojedinačnih faktora koji dovode do povećane koncentracije slobodnih radikala (tj. oksidativnog stresa) i narušavaju kvalitet spermograma kao i njihov uticaj na fluidnost ćelijske membrane spermatozoida. Rana i pravovremena detekcija slobodnih radikala  je od presudnog značaja za homeostazu čitavog organizma. Adekvatna  fluidnost membrane spermatozoida je neophodna za njihovu pokretljivost i za fuziju spemratozoida sa jajnom ćelijom. Za održavanje homeostaze organizma neophodni su i antioksidanti. Glutation i askorbinska kiselina su neenzimski antioksidanti, gde se nakon njihove primene beleže bolji nalazi spermograma.

 

Ključne reči:

spermatozoid, slobodni radikal, oksidativni stres, polinezasićene masne kiseline (PUFA), fluidnost, glutation, askorbinska kiselina.

 

 

 

Abstract

 

According to data from the World Health Organization (WHO), the rate of infertility is constantly increasing. This is particularly evident among younger men, which is significant because sperm quality and male fertility are important indicators of not only reproductive but also general health. The aim of this review article is to determine the correlation and significance of individual factors that lead to increased concentrations of free radicals (i.e., oxidative stress) and impair semen quality, as well as their impact on the fluidity of sperm cell membranes. Early and timely detection of free radicals is crucial for the homeostasis of the entire organism. Adequate membrane fluidity of sperm is necessary for their motility and for the fusion of sperm with the egg cell. Antioxidants are also essential for maintaining the homeostasis of the organism. Glutathione and ascorbic acid are non-enzymatic antioxidants, and their application results in improved semen quality.

 

Key words:

spermatozoon, free radical, oxidative stress, polyunsaturated fatty acids (PUFA), fluidity, glutathione, ascorbic acid.

 

 

 

 

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PDF: 05-Živić T. et al MD-Medical Data 2024;16(2) 105-108.pdf