md-medicaldata

Authors

 

Borislav Golijan¹, Jelena Ilić Sabo^2,3, Željka Panić², Miloš Pantelić^1,4, Igor Tešić<sup>1

1</sup>Klinika za ginekologiju i akušerstvo, Klinički Centar Vojvodine, Novi Sad, Srbija
²Katedra za histologiju i embriologiju, Medicinski fakultet, Univerzitet u Novom Sadu, Novi Sad, Srbija
³Centar za patologiju i histologiju, Klinički Centar Vojvodine, Novi Sad, Srbija
⁴Katedra za ginekologiju i akušerstvo, Medicinski fakultet, Univerzitet u Novom Sadu, Novi Sad, Srbija

 

UDK: 618.14-006

The paper was received / Rad primljen: 30.03.2024

Accepted / Rad prihvaćen: 05.04.2024.

 

Correspondence to:

Jelena Ilić Sabo
Univerzitet u Novom Sadu, Klinički Centar Vojvodine,
Centar za patologiju i histologiju,
Medicinski fakultet u Novom Sadu,
e-mail: jelena.ilic-sabo@mf.uns.ac.rs

 

 

Sažetak

 

 

Endometrioza predstavlja benigno ginekološko stanje koje podrazumeva prisustvo endometrijuma (žlezda i strome) van mesta njegovog normalnog razvoja. U zavisnosti od veličine i lokalizacije ekstrauterinog endometrijalnog tkiva, razlikujemo tri tipa endometrioze: površna endometrioza, endometrioza u vidu ovarijalne ciste i duboka endometrioza. S obzirom na najčešće simptome endometrioze u vidu bola i infertiliteta glavni terapeutski pristup je usmeren ka smanjenju simptoma i povećanju fertiliteta. U lečenju su do sada primenjivani konzervativni hiruški tretman, radikalna hirurgija, medikamentozna terapija, kao i preventivne metode. Jod je esencijalni element neophodan za metabolizam štitaste žlezde, dojke, jajnika, endometrijuma i trophoblasta, a učestvuje i u  metabolizmu leukocita i proizvodnji citokina uz imunomodulatornu ulogu. Ranija istraživanja ukazuju na sponu između malog unosa joda i efekta na potencijalni razvoj neoplazmi gde ukazuje na nedostatak joda u razvoju tumora dojke, endometrijuma i jajnika. Samo od sebe se nameće značajno pitanje-ukoliko je smanjen unos joda uzrok razvoja estrogen stimulisanih tumora, da li istovremeno adekvatnim unosom joda možemo uticati na prevenciju razvoja endometrioze/povlačenje nastalih lezija?

 

Ključne reči:

endometriosis, infertility, iodine, prevention

 

 

 

Abstract

 

Endometriosis is a benign gynecological condition which involves the presence of the endometrium (gland and stroma) outside the place of it’s normal development. Depending on the size and localization of the extrauterine endometrial tissue, we distinguish three types of endometriosis: superficial endometriosis, endometriosis in the form of an ovarian cyst and deep endometriosis. Considering the most common symptoms of endometriosis are pain and infertility, the main therapeutic approach is aimed at reducing symptoms and increasing fertility. So far, conservative surgical treatment, radical surgery, drug therapy and preventive methods have been used in the treatment. Iodine is an essential element necessary for the metabolism of the thyroid gland, breast, ovary, endometrium and trophoblast, and it also participates in the metabolism of leukocytes and the production of cytokines with an immunomodulatory role. Earlier researches indicate a link between low iodine intake and the effect on the potential development of neoplasms, where it indicates a lack of iodine in the development of breast, endometrial and ovarian tumors. By itself, an important question arises - if reduced intake of iodine is the cause of the development of estrogen-stimulated tumors, can at the same time adequate intake of iodine affect the prevention of the development of endometriosis/regression of the lesions?

 

Keywords:

endometrioza, infertilitet, jod, prevencija

 

 

 

 

References:

1. Kalaitzopoulos DR, Samartzis N, Kolovos GN, Mareti E, Samartzis EP, Eberhard M, et al. Treatment of endometriosis: a review with comparison of 8 guidelines. BMC Women’s Health. 2021;21(1):397. doi: 10.1186/s12905-021-01545-5. PMID: 34844587; PMCID: PMC8628449.
2. Imperiale L, Nisolle M, Noël J-C, Fastrez M. Three Types of Endometriosis: Pathogenesis, Diagnosis and Treatment. State of the Art. J Clin Med. 2023;12(3):994. https://doi.org/10.3390/jcm12030994
3. Barnard ND, Holtz DN, Schmidt N, Kolipaka S, Hata E, Sutton M, et al. Nutrition in the prevention and treatment of endometriosis: A review.  Front Nutr. 2023;10: DOI=10.3389/fnut.2023.1089891
4. Piccolo CL, Cea L, Sbarra M, De Nicola AM, De Cicco Nardone C, Faiella E, et al. Magnetic Resonance Roadmap in Detecting and Staging Endometriosis: Usual and Unusual Localizations. Appl Sci. 2023; 13(18):10509. https://doi.org/10.3390/app131810509
5. Amro B,  Ramirez A,  Alsuwaidi S, Almaamari B, Hakim Z, Tahlak M, et al. New Understanding of Diagnosis, Treatment and Prevention of Endometriosis. Int J Environ Res Pub Health. 2022; 19:6725. https:// doi.org/10.3390/ijerph19116725
6. Brookmeyer C, Fishman EK, Sheth S. Emergent and unusual presentations of endometriosis: pearls and pitfalls. Emerg Radiol. 2023; 30:377–85. https://doi.org/10.1007/s10140-023-02128-7
7. Rocha TP, Andres MP, Carmona F, et al. Deep Endometriosis: the Involvement of Multiple Pelvic Compartments Is Associated with More Severe Pain Symptoms and Infertility. Reprod Sci. 2023; 30:1668–75. https://doi.org/10.1007/s43032-022-01104-9
8. Gkegkes ID,  Iavazzo C,  Iatrakis G,  Iavazzo PE,  Pechlivani F,  Antoniou E, et al, Robotic Management of Endometriosis: Discussion of Use, Criteria and Advantages: a Review of the Literature.  Acta Med. 2020; 62(4):147-9. 10.14712/18059694.2020.3.
9. Lamceva J, Uljanovs R, Strumfa I. The Main Theories on the Pathogenesis of Endometriosis. Intern J Mol Sci. 2023; 24(5):4254. https://doi.org/10.3390/ijms24054254
10. Allaire C, Bedaiwy MA,  Yong PJ. Diagnosis and management of endometriosis.
11. CMAJ.  2023; 195(10):E363-E71. DOI: https://doi.org/10.1503/cmaj.220637
12. Ceccaroni M, Bounous VE, Clarizia R, Mautone D, Mabrouk M. Recurrent endometriosis: a battle against an unknown enemy. Eur J Contracept Reprod Health Care. 2019; DOI: 10.1080/13625187.2019.1662391
13. Shrikhande A, Patil S, Subhan M, Moody E, Natarajan J, Tailor Y, et al.  A Comprehensive Treatment Protocol for Endometriosis Patients Decreases Pain and Improves Function. Int J Women’s Health. (2023; 15:91-101. DOI: 10.2147/IJWH.S365637
14. Ferrero S, Evangelisti G, Barra F. Current and emerging treatment options for endometriosis. Expert Opin Pharmaco. 2018; DOI: 10.1080/14656566.2018.1494154
15. Elbasueny B, Geerts M, Yang E, Allaire C, Yong PJ, Bedaiwy MA. Medical treatments of endometriosis: a review. Reprod Dev Med. 2023; 7(3):166-79. September 2023. | DOI: 10.1097/RD9.0000000000000053
16. Dubrovina SO, Berlim YD, Alexandrina AD, Vovkochina MA, Bogunova DY, Gimbut VS, et al. Modern ideas about the diagnosis and treatment of endometriosis. Obstet Gynecol. 2023; 2:146-53. doi: 10.18565/aig.2023.43
17. Guo SW, Martin DC. The perioperative period: a critical yet neglected time window for reducing the recurrence risk of endometriosis? Hum Reprod. 2019; 34(10):1858-65. doi: 10.1093/humrep/dez187. PMID: 31585460.
18. O’Brien L, Morarasu S, Morarasu BC, et al. Conservative surgery versus colorectal resection for endometriosis with rectal involvement: a systematic review and meta-analysis of surgical and long-term outcomes. Int J Colorectal Dis. 2023; 38:55. https://doi.org/10.1007/s00384-023-04352-6
19. Yalçın Bahat P, Ayhan I, Üreyen Özdemir E, İnceboz Ü, Oral E. Dietary supplements for treatment of endometriosis: A review. Acta Biomed. 2022; 93(1):e2022159. doi: 10.23750/abm.v93i1.11237. PMID: 35315418; PMCID: PMC8972862.
20. Mazza E, Troiano E, Mazza S, Ferro Y, Abbinante A, Agneta MT, et al. The impact of endometriosis on dietary choices and activities of everyday life: a cross-sectional study. Front Nutr. 2023 10:1273976. doi: 10.3389/fnut.2023.1273976. PMID: 37810932; PMCID: PMC10559972.
21. Bilal MY, Dambaeva S, Brownstein D, Kwak-Kim J, Gilman-Sachs A,  Beaman KD. Iodide Transporters in the Endometrium: A Potential Diagnostic Marker for Women with Recurrent Pregnancy Failures. Med Princ Pract. 2020; 29(5):412–21. https://doi.org/10.1159/000508309
22. Mathews DM, Johnson NP, Sim RG, O’Sullivan S, Peart JM, Hofman PL.  Iodine and fertility: do we know enough? Hum Reprod. 2021; 36(2):265-74. https://doi.org/10.1093/humrep/deaa312
23. Stadel BV. Dietary iodine and risk of breast, endometrial, and ovarian cancer. Lancet. 1976;1(7965):890-1. doi: 10.1016/s0140-6736(76)92102-4. PMID: 58152.
24. Kumar KD, Huntriss R, Green E, Bora S, Pettitt C. Development of a nutrition screening tool to identify need for dietetic intervention in female infertility. J Hum Nutr Diet. 2022; https://doi.org/10.1111/jhn.13055
25. Schaffner M, Mühlberger N, Conrads-Frank A, Qerimi Rushaj V, Sroczynski G, Koukkou E, et al. Benefits and Harms of a Prevention Program for Iodine Deficiency Disorders: Predictions of the Decision-Analytic EUthyroid Model. Thyroid. 2021;31(3):494-508. doi: 10.1089/thy.2020.0062. PMID: 32847437.

26. The Krakow Declaration on Iodine: Tasks and Responsibilities for Prevention Programs Targeting Iodine Deficiency Disorders. Eur Thyroid J. 2018;7(4):201-204. doi: 10.1159/000490143. PMID: 30283738. PMCID: PMC6140595.
27. Schaffner M, Rochau U, Stojkov I, Qerimi Rushaj V, Völzke H, Marckmann G, et al. Barriers Against Prevention Programs for Iodine Deficiency Disorders in Europe: A Delphi Study. Thyroid. 2021; 31(4):649-57. doi: 10.1089/thy.2020.0065. PMID: 32912084.
    

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