md-medicaldata

Authors

 

Nikola Gardić^1,3, Aleksandra Lovrenski^1,3, Dejan Miljković^1,3, Milorad Bijelović³, Dejan Vučković^1,3, Goran Đenadić⁴, Dušan Lalošević<sup>1,2

1</sup>Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
²Pasteur Institute Novi Sad
³Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia
⁴General Hospital „Đorđe Joanović“, Clinical Pathology Department, Dr Vase Savića br. 5, 23101 Zrenjanin

 

UDK: 616.24-022.82:582.284.41

The paper was received / Rad primljen: 15.11.2023.

Accepted / Rad prihvaćen: 04.12.2023.

 

Correspondence to:

Prof. dr Dušan Lalošević,
Pasterov zavod
Novi Sad, Hajduk Veljka 1
Mob: 064/1370912
e-mail: dusan.lalosevic@gmail.com

 

 

Sažetak

 

 

Uvod: Gljivične infekcije postaju veliki problem u javnom zdravlju u eri globalnog povećanja broja imunokompromitovanih pacijenata. Radiološka manifestacije ove bolesti obuhvata širok spektar diferencijalnih dijagnoza uključujući i maligne bolesti. Prikaz slučaja: Prikazujemo slučaj pacijenta koji je podvrgnut hirurškom lečenju u cilju tretmana radiološki uočene promene u plućima. U otisnutim citološkim razmazima bojenim metodama Diff-Quik, GMS i PAS i histološkim uzorcima bojenim metodama H&E, GMS i PAS prisutna je histološka slika nekrotične granulomatozne upale sa prisutnim gljivicama, okruglog do ovalnog oblika, prečnika od 2-15 µm koje su GMS i PAS pozitivne. Na osnovu citološke i histološke morfološke slike gljivice pripadaju specijesu Cryptococcus neoformans. Zaključak: Gljivične infekcije pluća su jedna od diferencijalnih dijagnoza radiološki verifikovanih plućnih promena koje su suspektno maligne. Metoda izbora za takve lezije je histološka verifikacija dijagnoze. Citologija otiska se pokazaka kao korisna metoda u dijagnostici granulomatoznih upala i identifikaciji organizama.

 

Ključne reči:

gljivične infecije; kriptokokoza pluća; diferencijalna dijagnoza; citologija otiska

 

 

 

Abstract

 

Introduction: Fungal infections are becoming a major public health problem in an era of global increase in the number of immunocompromised patients. Radiological manifestations of this disease include a wide range of differential diagnoses, including malignant diseases. Case report: We present the case of a patient who underwent for surgical treatment as a therapeutic procedure for radiologically verified lung mass. Imprint smear stained with Diff-Quik, GMS and PAS, as well as in histological samples stained H&E, GMS, and PAS showed necrotizing granulomatous inflammation with presence of rounded/oval shaped,  ranging from 2-15 µm fungi which were GMS and PAS positive. Based on cytological and histological analysis fungi belongs to the Cryptococcus neoformans species. Conclusion: Fungal lung infections are one of the differential diagnoses of lung lesions that are suspicious of malignancy. For such lesions, the method of choice for diagnosis is histological verification. Imprint cytology smears are a helpful tool in demonstrating granulomatous inflammation and identifying organisms.

 

Key words:

fungal infections; lung cryptococcosis; differential diagnosis; imprint cytology

 

 

 

 

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PDF: 10-Gardić N. et al. MD-Medical Data 2023;15(3) 115-118.pdf