md-medicaldata

Authors

 

Jelena Amidžić^1,2, Milana Bosanac¹, Natali Rakočević¹, Željka Panić¹, Dragana Tegeltija^1,3, Matilda Đolai<sup>1,4

1</sup>Univerzitet u Novom Sadu, Medicinski fakultet Novi Sad, Novi Sad, Srbija
²Opšta bolnica Vrbas, Odsek za patologiju i citologiju, Vrbas, Srbija
³Institut za plućne bolesti Vojvodine, Služba za patološko-anatomsku i molekularnu dijagnostiku, Sremska Kamenica, Srbija
⁴Univerzitetski klinički centar Vojvodine, Centar za patologiju i histologiju, Novi Sad, Srbija

 

UDK: 611.663.018.7

The paper was received / Rad primljen: 25.03.2023.

Accepted / Rad prihvaćen: 06.04.2023.

 

Correspondence to:

doc. dr Jelena Amidžić
Odsek za patologiju i citologiju,
Opšta bolnica Vrbas
dr Milana Čekića 4,
21460 Vrbas, Srbija
telefon: +381 659290807
e-mail: jelena.amidzic@mf.uns.ac.rs

 

 

Sažetak

 

 

U grliću materice se histološki razlikuju dva regiona: ektocerviks (vaginalna porcija) i endocervikalni deo. Osnovna histološka razlika između ovih delova se ogleda u epitelu koji oblaže sluznicu. Histološke osobenosti endocervikalnog dela grlića materice u dostupnoj literaturi nisu detaljno proučene i postoje mnoga neodgovorena pitanja u pogledu opštih kvantitativnih histomorfoloških karakteristika, kao i u pogledu dobno zavisnih promena ovih parametara. U ovoj studiji su morfometrijskim metodama (linearnim i stereološkim merenjem) analizirani histološki preparati grlića materice obojeni standarnim hematoksilin /eozin bojenjem s ciljem da se odrede prosečne i referentne vrednosti opštih histoloških parametara. Analiziran je broj endocervikalnih žlezda po santimetru dužine endocerviksa, dubina endocervikalnih žlezda i visina endocervikalnog epitela. Obrađeno je ukupno 100 isečaka grlića materice, koji su podeljeni na osnovu godina starosti pacijentkinja u 5 podgrupa kako bi se utvrdilo da li postoje dobno zavisne razlike u vrednostima navedenih parametara.
Na osnovu rezultata ovog istraživanja referentna vrednost broja endocervikalnih žlezda po santimetru dužine je 13 - 29 žl/cm, dubine endocervikalnih žlezda je 1,3 - 4 mm a visine epitelnih ćelija endocerviksa je 24 - 46 μm. Kod perimenopauzalnih žena, starosti od 40 do 49 godina je nađena najveća prosečna vrednost dubine endocervikalnih žlezda i prosečne visine epitela endocerviksa.

 

Ključne reči:

endocerviks; histologija; cervikalna sluznica; morfometrijska analiza.

 

 

 

Abstract

 

In histologic terms, there are two different regions in the cervix: ectocervix (vaginal portion) and endocervical part. The main histologic difference between these two parts is reflected in the epithelium that coats the mucous. Histologic irregularities of the endocervical part of the cervix have not been studied in details in the available literature and there are many unanswered questions relating to general quantitative morphological features, as well as regarding age-dependent changes of such parameters. In this study, morphometric methods were used (by linear and stereological measuring) to conduct histologic analysis of cervical preparations stained by standard hematoxylin/eosin stains, with a goal to determine the average and reference values of general histologic parameters of the endocervical part of cervix. The number of endocervical glands per centimeter of endocervix length, the depth of endocervical glands and the height of endocervical epithelium were analyzed. A total of 100 cervical specimens was processed, and they were divided into 5 subgroups on the basis of patients’ age in order to determine if there are any age-dependent differences in the values of the mentioned parameters.
On the basis of the results of this research, the reference value for the number of endocervical glands per centimeter of length is 13 - 29 gl/cm, for the depth of endocervical glands is 1.3 - 4 mm and for the height of endocervical epithelium cells is 24 - 46 μm. The highest average value of the depth of endocervical glands as well as average height of endocervical epithelium were found with women in perimenopause, aged between 40 and 49.

 

Key words:

endocervix; histology; cervical mucosa; morphometric analysis.

 

 

 

 

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PDF: 02-Amidžić J. et al MD-Medical Data 2023;15(1-2) 011-016.pdf