md-medicaldata

Authors

 

Anita Birinji¹, Željko Mihaljev², Dušan Lalošević³, Marija Marin<sup>1

1</sup>Univerzitet u Beogradu, Biološki fakultet, Studentski trg 16, 11000 Beograd
²Naučni institut za veterinarstvo ,,Novi Sad”, Rumenački put 20, 21113 Novi Sad, Srbija
³Univerzitet u Novom Sadu, Medicinski fakultet i Pasterov zavod Novi Sad, Hajduk Veljkova 1, 21000 Novi Sad, Srbija

 

UDK: 615.9:546.19
616-099:546.19

The paper was received / Rad primljen: 01.12.2021.

Accepted / Rad prihvaćen: 01.06.2022.

 

Correspondence to:

Birinji Anita
e-mail: ani.birinji@gmail.com

 

 

Sažetak

 

 

Prisustvo arsena u životnoj sredini predstavlja ozbiljan zdravstveni problem. Na teritoriji Srbije najviše je prisutan u Vojvodini. Postavili smo eksperimentalni model izloženosti arsena u vodi za piće kroz tri generacije miševa. Koncentracija arsena je određena prema formuli za preračunavanje vrednosti kojima mogu biti izloženi ljudi u vodovodu Banata na animalni model. Postavljene su dve grupe miševa eksponiranih arsen (III)-oksidu od 10,6 mg/L i deset puta veća, 106 mg/L. U radu su prikazani rezultati sadržaja ukupnog arsena deponovanog u organima mužjaka miševa (jetra, bubrezi, testisi, mozak) praćeni kroz tri uzastopne generacije. Rezultati ukazuju da se arsen taloži u organima i da sadržaj ukupnog arsena tokom generacija ne opada. Nisu registrovane promene u aktivnosti miševa, ishrani, ni većem gubitku telesne težine. Nema registrovanih tumoroznih promena na spoljašnjoj i unutrašnjoj građi tela. Nisu zabeležena masovna uginuća životinja tokom ogleda.

 

 

 

Ključne reči:

arsen(III)-oksid, miševi, eksperimentalni model.

 

 

 

Abstract

The presence of arsenic in the environment is a serious health problem. On the territory of Serbia, it is most present in Vojvodina. We set up an experimental model of arsenic exposure in drinking water through three generations of mice. The concentration of arsenic was determined according to the formula for converting the values to which people can be exposed in the Banat water supply system to the animal model. Two groups of mice exposed to arsenic (III)-oxide of 10.6 mg/L and ten times higher, 106 mg/L, were placed. The paper presents the results of the content of total arsenic deposited in the organs of male mice (liver, kidneys, testicles, brain) followed through three consecutive generations. The results indicate that arsenic is deposited in organs and that the content of total arsenic does not decrease over generations. No changes were registered in the mice's activity, diet, or significant loss of body weight. There are no registered tumorous changes on the external and internal structure of the body. No mass deaths of animals were recorded during the experiment.

 

 

Key words:

arsenic(III)-oxide, mice, experimental model.

 

 

 

 

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PDFBirinji A. et al. MD-Medical Data 2022;14(1-2): 041-044