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KIM1 – NOVI BIOMARKER BUBREŽNOG OŠTEĆANJA /

KIM-1 – A NEW BIOMARKER OF KIDNEY INJURY

Authors

 

Maja Samardžić Lukić1, Milana Bosanac2, Dejan Dobrijevic3, Natasa Kovač1, Dragomir Ćuk4, Borko Milanović2,5, Bojana Andrejić Višnjić2

1Institut za zdravstvenu zaštitu dece i omladine, Odeljenje za nefrologiju
2Medicinski fakultet Novi Sad, Univerzitet u Novom Sadu
3Institut za zdravstvenu zaštitu dece i omladine, Odeljenje za laboratorijsku dijagnostiku
4Klinički centar Vojvodine, Centar za histologiju i patologiju
5Institut za zdravstvenu zaštitu dece i omladine, Odeljenje za imunologiju, alergologiju i reumatologiju

 

UDK: 616.61-008.64:577.1


The paper was received / Rad primljen: 10.12.2021.

Accepted / Rad prihvaćen: 18.12.2021.

 


Correspondence to:


Bojana Andrejić Višnjić
Hajduk Veljkova 3, 21000 Novi Sad
tel: 063 1669300
e-mail: bojana.andrejic-visnjic@mf.uns.ac.rs

 

 

Sažetak

 

Broj osoba sa bubrežnim oštećenjem svakodnevno se povećava u svetu, i decenijama, u kliničkoj praksi, postoji potraga za idealnim markerom koji će rano detektovati bubrežno oštećenje. Jedan od markera u fazi istraživanja je i kidney injury molecule-1 (KIM-1), kome se može odrediti koncentracija u serumu i urinu ili stepen tkivne ekspresije. Većina autora se slaže da kod zdravih ososba nema KIM-1 u urinu i serumu. Koncentracije KIM-1 rastu brzo po oštećenju proksimalnih tubula (nakon 5-6h) i koreliraju sa padom jačine glomerulske filtracije i stepenom bubrežnog oštećenja. Ipak, nije razjašnjen mehanizam delovanja i da li je u stvari marker reparacije ili progresije oštećenja putem indukovanja inflamacije i fibroze.
Kod pedijatrisjke populacije, podaci su oskudni i nisu definisane referentne vrednosti, ali je ustanovljeno da su koncentracije KIM-1 niže kod dece određene etničke pripadnosti, sa pikom vrednosti u jutarnjim satima. 
Tkivna ekspresija KIM-1 je prisutna u svim stanjima i oboljenjima gde postoji oštećenje proksimalnih tubula, nezavisno od etiologije. Postoji mali broj studija o postojanju tj izostanku tkivne eskpresije kod zdravih tkiva, i daju suprotstavljene podatke. Još su ređa istraživanja ekspresije u fetalnim tkivima, ali podaci za sada govore da KIM-1 može biti indikator postojanja intrauterinog i/ili antemortem oštećenja usled hipoksije. Dalja istraživanja na fetalnom materijalu i tkivima pedijatrijske populacije je od esencijalnog značaja.

 

Ključne riječi

KIM1, bubrežno oštećenje, glomerulska filtracija

 

 

 

Abstract

 

The number of people with kidney diseases increases worldwide, and for decades, in clinical practice, there has been a search for the ideal marker that will detect kidney damage early. One of the markers in the research phase is kidney injury molecule-1 (KIM-1), which can be determined as serum and/or urine concentrations or the degree of tissue expression. Most authors agree that in healthy individuals there is no KIM-1 in urine and serum. Concentrations of KIM-1 increase rapidly after proximal tubules damage (after 5-6 h) and correlate with a decrease in glomerular filtration rate and the degree of renal damage. However, the mechanism of action has not been clarified and whether it is in fact a marker of reparation or progression of damage by inducing inflammation and fibrosis.
In the pediatric population, data are scarce, and no reference values ​​have been defined, but KIM-1 concentrations have been found to be lower in children of a certain ethnicity, with peak values ​​in the morning.
Tissue expression of KIM-1 is present in all conditions and diseases where there is damage to the proximal tubules, regardless of the etiology. There are a small number of studies on the existence or absence of tissue expression in healthy tissues, and they give conflicting data. Expression studies in fetal tissues are even rarer, but data for now suggest that KIM-1 may be an indicator of intrauterine and/or antemortem damage due to hypoxia. Further research on fetal material and tissues of the pediatric population is essential.


Key words:

KIM-1, kidney diseases, glomerular filtration

 

 

 

 

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PDF: 12-MD-Vol 13 No 3-4 Sept-Dec 2021_Samardžić Lukić et al.pdf

 

 

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