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HISTOMORFOLOŠKE KARAKTERISTIKE REGIONALNIH, REAKTIVNO IZMENJENIH LIMFNIH ČVOROVA KOD KARCINOMA KOLONA /

HISTOMORPHOLOGICAL CHARACTERISTICS OF REGIONAL, REACTIVELY CHANGED LYMPH NODES IN COLON CARCINOMA

Authors

 

Milana Bosanac1, Vanja Tovilović2, Jelena Ilić Sabo 1,2, Bojana Andrejić-Višnjić 1, Nevena Stanulović1,3, Ivanka Perčić2 , Bosiljka Krajnović4

1Medicinski fakultet, Univerzitet u Novom Sadu, Srbija
2Klinički centar Vojvodine, Novi Sad, Srbija
2Institut za onkologiju Vojvodine, Sremska Kamenica, Srbija
2Institut za plućne bolesti Vojvodine, Sremska Kamenica, Srbija

 

UDK: 572.51-053.6
613.71/.74-053.6


The paper was received / Rad primljen: 29.10.2021.

Accepted / Rad prihvaćen: 15.12.2021.

 


Correspondence to:


doc. dr Jelena Ilić Sabo
Medicinski fakultet Univerziteta u Novom Sadu, Srbija
Hajduk Veljkova 3, 21000 Novi Sad, Srbija
telefon: +38163303585
e-mail: jelena.ilic-sabo@mf.uns.ac.rs

 

 

Sažetak

 

Uvod: Limfni čvorovi imaju ulogu filtriranja limfe, te sprečavanja daljeg širenja infekcije/tumora. Metastaze predstavljaju širenje tumora sa primarnog mesta nastanka tumora. Karcinom kolona je jedan od najčešćih malignih tumora. Ciljevi istraživanja su bili: izmeriti veličinu limfnog čvora, odrediti broj primarnih i sekundarnih limfoidnih folikula, izračunati njihov odnos u svakom limfnom čvoru. Semikvantitativno proceniti broj blasta u germinativnom centru sekundarnih limfoidnih folikula, proceniti proširenost sinusa, sinus histiocitozu i hiperemiju. Kao i ispitati stepen korelacije između navedenih parametara. Materijal i metode: Sprovedena je retrospektivna studija. Podaci su dostavljeni u Centar za patologiju i histologiju sa Klinike za abdominalnu hirurgiju Kliničkog Centra Vojvodine. Analizirano je 50 regionalnih, reaktivno izmenjenih limfnih čvorova. Parametri su ocenjivani semikvantitativno, a rezultati su statistički obrađeni u programima  Microsoft office Excel 2010 i Social Science Statistics. Rezultati: Prosečni dijametar reaktivno izmenjenih regionalnih čvorova je 5,23 mm. U 70% čvorova prosečan broj blasta se kreće između 1 i 5. U 54% čvorova uočava se izražena ravnomerna proširenost sinusa. U 48% analiziranih limfnih čvorova prisutan je umeren broj histiocita u sinusima. Hiperemija je odsutna u 42% analiziranih limfnih čvorova. U 62% ispitanih slučajeva nalaze se samo reaktivno izmenjeni limfni čvorovi. Korelacija varira u zavisnosti od poređenih parametara.  Zaključak: U regionalnim, reaktivno izmenjenim limfnim čvorovima uočavaju se promene u vidu proširenosti sinusa, sinus histiocitoze, hiperemije i povećanog broja sekundarnih limfoidnih folikula sa povećanim brojem blasta u germinativnim centrima. Među pojedinim poređenim parametrima uočavamo značajnu korelaciju, dok kod nekih ne postoji.

 

Ključne riječi

limfni čvor; karcinom kolona; metastaza

 

 

 

Abstract

 

Introduction: Lymph nodes have the role of filtering the lymph, and preventing the further spread of infection / tumor. Metastases are the spread of a tumor from the primary site of tumor formation. Colon cancer is one of the most common malignant tumors. The aims of the study were: to measure the size of the lymph node, to determine the number of primary and secondary lymphoid follicles, to calculate their ratio in each lymph node. Semiquantitatively assess the number of blasts in the germinal center of secondary lymphoid follicles, assess sinus dilatation, sinus histiocytosis and hyperemia. As well as to examine the degree of correlation between the stated parameters. Material and methods: A retrospective study was conducted. The data were submitted to the Center for Pathology and Histology from the Clinic for Abdominal Surgery of the Clinical Center of Vojvodina. 50 regional, reactively altered lymph nodes. The parameters were evaluated semiquantitatively, and the results were statistically processed in Microsoft office Excel 2010 and Social Science Statistics. Results: The average diameter of reactively altered regional nodes is 5.23 mm. In 70% of nodes, the average number of blasts ranges between 1 and 5. In 54% of nodes, a pronounced uniform expansion of the sinuses is observed. A moderate number of histiocytes in the sinuses is present in 48% of the analyzed lymph nodes. Hyperemia is absent in 42% of analyzed lymph nodes. In 62% of the examined cases, there are only reactively altered lymph nodes. The correlation varies depending on the compared parameters. Conclusion: In regional, reactively altered lymph nodes, changes in the form of sinus dilatation, sinus histiocytosis, hyperemia and increased number of secondary lymphoid follicles with increased number of blasts in germinal centers. We notice a significant correlation between some of the compared parameters, while some do not. 


Key words:

lymph node; colon cancer; metastasis

 

 

 

 

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PDF: 08-MD-Vol 13 No 3-4 Sept-Dec 2021_Bosanac M. et al.pdf

 

 

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