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HORMONALNI LABORATORIJSKI MARKERI OVARIJSKE REZERVE /

HORMONAL LABORATORY MARKERS OF OVARIAN RESERVE

Authors

 

Almedina Hajrović1, Snežana Unčanin1,2, Sanela Hajro1,2, Selvedina Duškan1,2

1Fakultet zdravstvenih studija, Univerzitet u Sarajevu
2Univerzitetski Klinički Centar u Sarajevu

 

UDK: 618.177-074 : 577.175.6


The paper was received / Rad primljen: 12.09.2021.

Accepted / Rad prihvaćen: 30.09.2021.

 


Correspondence to:


Mr. Almedina Hajrović, ass.
Fakultet zdravstvenih studija
Univerzitet u Sarajevu
e-mail: almedina.ha@hotmail.com

 

 

Sažetak

 

Obzirom da su vrlo česti problemi današnjice neplodnost različite etiologije, kao i  pronalazak adekvatnog terapijskog postupka, neizostavno i vrlo važnu ulogu ima laboratorijsko određivanje korisnih hormonskih markera ovarijske rezerve. Od najznačajnijih hormonskih screening testova  neizostavan je Anti-Müllerov hormon (AMH), a potom folikostimulirajući hormon (FSH), estradiol koji su precizniji testovi u odnosu na inhibin B i klomifen citratni test  (CC) test. Anti-Müllerov hormon (AMH) je najznačajniji laboratorijski prediktor ovarijske rezerve. Samostalno određivanje koncentracije estradiola i koncentracije FSH ne bi trebalo se upotrebljavati u procjeni ovarijske rezerve, prvenstveno zbog varijacije hormona tokom menstrualnog ciklusa. Vrijednosti estradiola jedino mogu poslužiti kao unutarnja kontrola faze menstrualnog ciklusa, dok FSH za procjenu folikulogeneze, perimenopauzalnog statusa, hipergonadotropnog i hipogonadotropnog gonadizma, te centralnog preuranjenog puberteta. Međutim, AMH u kombinaciji sa hormonima kao što su FSH i estradiol ljekar uz druge dijagnostičke (ultrazvučne) procedure dobiva sagledivu sliku u smislu terapijskog tretmana, što i ukazuje na sam značaj laboratorijskog određivanja navedenih hormona u procjeni ovarijske rezerve. Kada je u pitanju osjetljivost i specifičnost metoda određivanja navedenih hormona, iste su vremenom razvijane, te su imunohemijske metode u širokoj primjeni s zadovoljavajućom osjetljivošću i specifičnošću.

 

Ključne riječi

ovarijska rezerva, Anti-Müllerov hormon (AMH), FSH, estradiol, imunohemijske metode

 

 

 

Abstract

 

Given that very common problems today are infertility of various etiologies, as well as finding an adequate therapeutic procedure, inevitably and very important role is played by laboratory determination of useful hormonal markers of ovarian reserve. Of the most important hormone screening tests, the Anti-Müller hormone (AMH) is indispensable, followed by folcostimulating hormone (FSH), estradiol, which are more precise tests compared to inhibin B and the clomiphene citrate test (CC) test. Self-determination of estradiol concentration and FSH concentration should not be used in the assessment of ovarian reserve, primarily due to hormone variation during the menstrual cycle. Estradiol values ​​can only serve as an internal control of the menstrual cycle phase, while FSH to assess folliculogenesis, perimenopausal status, hypergonadotropic and hypogonadotropic gonadism, and central premature puberty. However, AMH in combination with hormones such as FSH and estradiol, along with other diagnostic (ultrasound) procedures, the doctor gets a clear picture in terms of therapeutic treatment, which indicates the importance of laboratory determination of these hormones in the assessment of ovarian reserve. When it comes to the sensitivity and specificity of the methods for determining these hormones, they have evolved over time, and immunochemical methods are widely used with satisfactory sensitivity and specificity.


Key words:

ovarian reserve, Anti-Müller hormone (AMH), FSH, estradiol, immunochemical methods

 

 

 

 

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PDF: 06-MD-Vol 13 No 3-4 Sept-Dec 2021_Hajrović A. et al..pdf

 

 

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