md-medicaldata

Authors

 

Igor Spasić ¹ , Milan Ubavić ¹, Biljana Vučković <sup>2

1</sup>Zavod za laboratorijsku dijagnostiku Medlab
²Katedra za patološku fiziologiju i laboratorijsku medicinu; Medicinki fakultet; 21000 Novi Sad

 

UDK: 616.441-074

The paper was received / Rad primljen: 26.08.2020.

Accepted / Rad prihvaćen: 28.08.2020.

 

Correspondence to:

Igor Spasić
Department of laboratory diagnostics Medlab,
Branimira Ćosića 21/15; 21000 Novi Sad,
AP Vojvodina, Republika Srbija
Mobile: 060/3003811;
e-mail: igsp92@gmail.com

 

 

Sažetak

 

Uvod: Šmitov sindrom ili autoimuni poliendokrini sindrom tipa 2 (APS-2) je autoimuni poremećaj koji se  karakteriše kombinacijom adrenalne insuficijencije, autoimunog hipotireoidizma (Hašimototireoiditisa i ređe Grejvs-Bazedovljeva bolest) i/ili dijabetesa melitusa. Primarni hipogonadizam, miastenia gravis i celijačna bolest takođe se sreću u sklopu ovog sindroma. Prikaz slučaja: Pacijentkinja starosti 27 godina javlja se na laboratorijsko ispitivanje u Zavod za laboratorijsku dijagnostiku Medlab. Navodi simptome slabosti, malaksalosti koji se javljaju iznenadno u tok udana, promene raspoloženja, čest osećaj gladi i gubitak svesti u nekoliko navrata. Simptomi su se ispoljili pre 6 meseci, a u poslednje vreme su sve intenzivniji. Pacijentkinja negira postojanje ranije dijagnostikovanih hroničnih oboljenja kao i bilo kakav vid terapije. Navodi da je u nekoliko navrata samostalno izmerila nivo tenzije 105/60 mmHg. Laboratorijski nalaz ukazao je na postojanje Hašimoto tireoiditisa, prisustvo hiponatrijemije kao i hipokortizolemiju. Daljim laboratorijskim ispitivanjem ustanovljeno je prisustvo povišenog titra antiadrenalnih antitela, dok je kompjuterizovanom tomografijom uočeno bilateralno smanjenje volumena nadbubrega. Zaključak: Prisustvo hipokortizolemije uz nespecifične simptome i znakove zahteva detaljnu dijagnostiku i procenu funkcije nadbubrega koja bi uključila ispitivanje funkcionalnosti sve tri funkcionalne zone korteksa, dok adekvatan odabir laboratorijskih testova može dovesti do pravovremene dijagnoze i ukazati na autoimunu etiopatogenezu oboljenja.

 

 

 

Ključne reči:

Šmitov sindrom, hipokortizolemija, Adisonova bolest, Hašimoto tireoiditis

 

 

Abstract

 

Introduction: Schmidt's syndrome or autoimmune polyendocrine syndrome type 2 (APS-2) is an autoimmune disorder characterized by a combination of adrenal insufficiency, autoimmune hypothyroidism (Hashimotothyroiditis and, less commonly, Graves-Bazedow's disease) and / or diabetes mellitus. Primary hypogonadism, myasthenia gravis, and celiac disease are also found in this syndrome. Case report: A 27-year-old female patient reports for a laboratory testing at the Medlab Laboratory Diagnostics Department. She cites symptoms of weakness, malaise that appear suddenly during the day, mood swings, a frequent feeling of hunger and loss of consciousness on several occasions. The symptoms appeared 6 months ago, and lately they have become more and more intense. The patient denies the existence of previously diagnosed chronic diseases as well as taking any type of therapy. She states that on several occasions she independently measured the tension which was 105/60 mmHg. The laboratory findings indicated the existence of Hashimoto's thyroiditis, the presence of hyponatremia as well as hypocortisolemia. Further laboratory examination revealed the presence of an elevated titer of antiadrenal antibodies, while computed tomography showed a bilateral decrease in adrenal volume. Conclusion: The presence of hypocortisolemia with nonspecific symptoms and signs requires detailed diagnostics and assessment of adrenal function, which would include examination of the functionality of all three functional zones of the cortex, while adequate selection of laboratory tests can lead to timely diagnosis and show the autoimmune etiopathogenesis of disease.

 

 

Key words:

Schmidt's syndrom, Addison's disease, hypocortisolism

 

 

References:

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PDF Spasić I. et al • MD-Medical Data 2020;12(3): 139-141