md-medicaldata

Authors

 

Kristina Stepanović^1,2, Jovana Prodanović^1,2, Mia Manojlović^1,2, Bojan Vuković^1,2, Maja Milanović^1,3, Nataša Milošević^1,3, Jan Suđi^1,3, Nataša Milić^1,3, Milica Medić Stojanoska<sup>1,2

1</sup>Univerzitet u Novom Sadu, Medicinski fakultet, Novi Sad, Srbija
²Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Novi Sad, Srbija
³Zavod za farmaciju, Medicinski fakultet, Univerzitet u Novom Sadu, Novi Sad Srbija

 

UDK: 616.43-008:661.8`078.4

The paper was received / Rad primljen: 06.03.2020.

Accepted / Rad prihvaćen: 15.03.2020.

 

Correspondence to:

dr Kristina Stepanović,
Klinika za endokrinologiju, dijabetes, bolesti metabolizma
Klinički centar Vojvodine, Novi Sad, Srbija
Medicinski fakultet, Univerzitet u Novom Sadu, Novi Sad, Srbija
e-mail: kristina.stepanovic@mf.uns.ac.rs

 

 

Sažetak

 

Ftalati predstavljaju grupu sveprisutnih hemikalija koje se nalaze u mnogim potrošačkim  proizvodima koje čovek svakodnevno upotrebljava. Za ftalate je poznato da su endokrini disruptori, odnosno da remete funkciju endokrinog sistema putem kompeticije sa endogenim hormonima, tako što se vezuju za receptore ili menjaju sintezu i metabolizam hormona. Potencijalni vidovi ekspozicije ftalatima jesu ingestija, inhalacija i apsorpcija preko kože. Smatra se da deluju preko nuklearnih receptora i preko njih utiču na regulaciji velikog broja funkcija ćelije, sa sposobnošću da menjaju samu strukturu ćelije i dovedu do poremećaja zdravlja.

 

 

Ključne reči:

Ftalati, Ftalatni metaboliti, Endokrini disruptori

 

 

Abstract

 

Phthalates represent a group of chemicals that are present in many consumer products being used on a day to day basis. They are known to act as endocrine disruptors which distort endocrine system function due to competition with endogenic hormones by adhering to the receptors or by changing the synthesis and metabolism of hormones. Potential ways of phthalate exposure are ingestion, inhalation and skin absorption. They are considered to interfere with nuclear receptors and in that way affect many parts of cell functioning by changing its structure and consecutively disrupting health.

 

 

Key words:

Phthalate, Phthalate metabolites, Endocrine disruptors

 

 

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PDF Stepanović K. et al.• MD-Medical Data 2020;12(1): 029-031