md-medicaldata

Authors

 

Dragica Bulajić¹, Jovana Drljača¹, Aleksandra Rakovac², Dejan Miljković³, Ivan Čapo³, Slobodan Sekulić⁴ , Branislav Bajkin<sup>5

1</sup>Univerzitet u Novom Sadu, Medicinski fakultet
²Univerzitet u Novom Sadu, Medicinski fakultet, Katedra za fiziologiju,
³Univerzitet u Novom Sadu, Medicinski fakultet, Katedra za histologiju i embriologiju,
⁴Univerzitet u Novom Sadu,Medicinski fakultet, Klinika za neurologiju, Klinički centar Vojvodine
⁵Univerzitet u Novom Sadu, Medicinski fakultet, Klinika za stomatologiju Vojvodine

 

UDK: 615.46:616.314

The paper was received / Rad primljen: 20.02.2019.

Accepted / Rad prihvaćen: 25.02.2019.

 

Correspondence to:

dr Dragica Bulajić
Univerzitet u Novom Sadu/Medicinski fakultet
Hajduk Veljkova 3, 21000 Novi Sad
Kontakt telefon: 064/ 3810866
e-mail: dragica.bulajic@uns.ac.rs

 

 

Sažetak

 

Materijali u tkivnom inženjeringu imaju dugu istoriju. Tradicionalno su za nadomešćavanje kosti korišćeni autogeni, alogeni, ksenogeni i aloplastični materijali.  Međutim, napreci u kliničkoj praksi su napravljeni, i to kao rezultat poboljšanja već postojećih materijala. Tkivno inženjerstvo podrazumeva zasejavanje ćelija na skafolde, i nakon kultivacije in vitro, implantaciju u telo kao zamenu za nedostajaće tkivo. Nakon toga nastupa proces regeneracije tkiva. Skafold omogućava ram i incijalnu podršku ćelijama da se pričvrste, proliferišu, diferentuju i stvore ekstracelularni matriks.  Veoma je poželjno da skafold imitira strukturu i svojstva humanog tkiva, kako bi se proces regeneracije i resorpcije odvijao sinhrono. Mnogo je faktora koji definišu dobar skafold, a neki od njih su poroznost, karakteristike površine, mehničke osobine, mogućnost inkorporacije ćelija i bioaktivnih molekula. U ovom radu, navedeni su skafoldi dostupni u klliničkom radu, istaknute su njhove prednosti i mane koje u budućnosti moraju da se poboljšaju.

 

 

Ključne reči:

skafoldi, tkivno inženjerstvo, polimeri, kompoziti, koštana regeneracija.

 

 

Abstract

 

Materials in tissue engineering have a long history. Traditionally, autogenic, allogenic, xenogenic and alloplastic materials have been used to replace bone defects, but advances in clinical practice have been made, as a result of the improvement of already existing materials. Tissue engineering  is actually planting cells on scaffolds, and after cultivation in vitro, implantation into the body as a substitute for the missing tissue. After that, the tissue regeneration process occurs. Scaffolds allow the frame and initial support for cells to attach, proliferate, deferent, and create an extracellular matrix. It is highly desirable for scaffold to imitate the structure and properties of human tissue, because process of regeneration and resorption process should be synchronously. There are many factors that define a good scaffold, like porosity, surface characteristics, mechanical properties, the ability to incorporate cells and bioactive molecules. The mentioned scaffolds are available in clinic work, and their advantages and disadvantages are highlight in this paper. All disadvantages need to be improved in the future..

 

Key words:

scaffolds,  tissue engineering, polymers, composites, bone regeneration

 

 

 

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