md-medicaldata

Authors

 

Aleksandra Lovrenski^1,2, Dragana Tegeltija^1,2, Željka Vrekić³, Bojana Andrejić Višnjić⁴, Siniša Maksimović², Anika Považan<sup>2,5

1</sup>Univerzitet u Novom Sadu, Medicinski fakultet, Katedra za patologiju
²Institut za plućne bolesti Vojvodine, Sremska Kamenica, Srbija
³Centar za potologiju i histologiju, Klinički centar Vojvodine, Novi Sad, Srbija
⁴Univerzitet u Novom Sadu, Medicinski fakultet, Katedra za histologiju i embriologiju
⁵Univerzitet u Novom Sadu, Medicinski fakultet, Katedra za mikrobiologiju i imunologiju

 

UDK: 616.24-002.828

The paper was received / Rad primljen: 12.12.2018.

Accepted / Rad prihvaćen: 27.12.2018

 

Correspondence to:

Aleksandra Lovrenski, MD, PhD, Assistant Professor
Department for Pathology, Institute for pulmonary diseases of Vojvodina
Put doktora Goldmana 4,
21204 Sremska Kamenica, Serbia
Mobile phone: +381 66 880 5321
e-mail: aleksandra.lovrenski@mf.uns.ac.rs

 

 

Sažetak

 

Uvod: Gljvice iz roda Aspergillus mogu da izazovu čitav spektar plućnih bolesti u zavisnosti od stanja imuniteta i postojećih plućnih oboljenja. Iako patohistološka dijagnostika predstavlja zlatni standard za postavljanje definitivne dijagnoze aspergiloze, prednost imaju serološke metode usled njihove manje invazivnosti i povoljnijeg profila komplikacija i kontraindikacija. Cilj: Cilj rada je bio da se utvrdi povezanost patohistološke i serološke dijagnoze kod pacijenata sa aspergilozom pluća lečenih u Institutu za plućne bolesti Vojvodine. Materijal i metode: Retrospektivno ispitivanje obuhvatilo je 33 pacijenata kod kojih je u periodu od juna 2012. do juna 2017. godine, na Institutu za plućne bolesti Vojvodine patohistološki i serološki dokazana aspergiloza pluća. Materijal za patohistološku i serološku analizu obrađen je u Centru za patologiju i Centru za mikrobiologiju, virusologiju i imunologiju Instituta. Rezultati: Od ukupno 33 pacijenta, aspergilom je dijagnostikovan kod 28 (85%) pacijenata, kod 2 (6%) pacijenta HNPA, IPA kod 2 (6%), a kod jednog (3%) ABPA. Najčešći komorbiditeti su bili: tuberkuloza kod 16 (49%) pacijenata, zatim karcinom pluća kod 7 (21%) pacijenata, bronhiektazije kod 5 (15%), HOBP kod 3 (9%) i akutna leukemija kod 2 (6%) pacijenta. Galaktomanan je bio pozitivan kod 20 (60%), a negativan kod 13 (40%). Vrednosti antitela su kod 30 (91%) pacijenata bile pozitivne, a kod 3 (9%) bile negativne. Zaključak: Patohistološka dijagnostika predstavlja jedini način za postavljanje definitivne dijagnoze aspergiloze, ali zbog invazivnosti, kontraindikacija i komplikacija, kao prva stepenica u postavljanju dijagnoze treba da se koriste serološka ispitivanja.

 

 

Ključne reči:

Aspergillus, galaktomanan, antitela, serološka dijagnostika, patohistološka dijagnostika.

 

 

Abstract

 

Introduction: Aspergillus spp. can cause a wide range of lung diseases, depending on the current state of immunity and the existing pulmonary diseases. Although histopathological diagnostics is a gold standard for setting a definite diagnosis of aspergillosis, serological methods are preferred because of their less invasiveness and more favorable profile of complication and contraindications. Goal: The objective of this study was to determine the relation of pathohistological and serological diagnosis of patients with aspergillosis. Material and Methods: This retrospective study included 33 patients with lung aspergillosis diagnosed at the Institute for Pulmonary Diseases of Vojvodina from June 2012 until June 2017 The material for pathohistological and serological analysis was processed at the Centre for Pathology and Center for Microbiology, Virology and Immunology of the Institute. Results: From total of 33 patients, aspergilloma was diagnosed at 28 (85%) patients, 2 (6%) patients had CNPA, 2 (6%) patient had IPA and one (3%) was diagnosed with ABPA.The most common comorbidities were: tuberculosis in 16 (49%) patients, lung carcinoma in 7 (21%) patients, bronchiectasis in 5 (15%), HOBP in 3 (9%) and acute leukemia in 2 (6%) patients. Galactomannan was positive in 20 (60%) and negative in 13 (40%). The antibody values were positive in 30 (91%) patients, and 3 (9%) were negative. Conclusion: Histopathological examination is the only way to set a definite diagnosis of aspergillosis, but due to invasiveness, contraindications and complications, serological tests should be used as the first step in diagnosis.

 

 

Key words:

Aspergillus; galactomannan; antibody; serological diagnostics; histopathological diagnostics.

 

 

References:

 

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PDF Lovrenski A. et al. • MD-Medical Data 2018;10(4): 191-196