md-medicaldata

Authors

 

Emilija Kostić^1,2, Maja Vujović<sup>1,2

1</sup>Zavod za sudsku medicinu Niš
²Medicinski fakultet, Univerzitet u Nišu

 

UDK: 665.584:661.882'022-14(497.11)

The paper was received / Rad primljen: 21.10.2018.

Accepted / Rad prihvaćen: 28.10.2018

 

Correspondence to:

Emilija Kostić
Univerzitet u Nišu, Medicinski fakultet
Zavod za sudsku medicinu
Bulevar dr Zorana Đinđića 81,
18000 Niš
e-mail: emilija293@gmail.com

 

 

Abstract

 

Nowadays, sunscreens are increasingly used worldwide to protect skin from UV radiation and prevent skin cancer. TiO2 and TiO2 nanoparticles (NPs) are the most commonly used in these preparations as physical blockers. There are studies that indicate that TiO2 and TiO2 NPs from sunscreen preparations can cause production ROS in vivo, which can cause cytotoxicity and genotoxicity. The largest number of studies show that there is no significant penetration of TiO2 and TiO2 NPs through healthy skin. Therefore, in this survey, content of TiO2 and TiO2 NPs in sunscreens on the Serbian market, was analyzed. There is a large number of preparations with different SPF (sun protection factor), and most have a SPF higher than 30. In preparations with SPF higher than 30, most commonly are physical blockers (TiO2 and TiO2 NPs) 63%, while in preparations with SPF less than 30, this percentage is twice as low. In the products of domestic manufacturers, the most common is TiO2, unlike the European manufacturers, where TiO2 NPs are mainly used. In sunscreens for children, there are at least TiO2 NPs, which is especially important because studies have shown that resorption is increased through sensitive and damaged skin.

 

 

Keywords:

sunscreens, TiO2, TiO2 NPs, Serbian market

 

 

Sažetak

 

Danas se u svetu sve više koriste preparati za sunčanje koji štite kožu od UV zračenja i njegovih eventualnih štetnih posledica. U tim preparatima od fizičkih blokatora najzastupljeniji su TiO2 i TiO2 u obliku nanočestica (nanoparticles-NPs). Postoje studije koje ukazuju da TiO2 i TiO2 NPs iz preparata za sunčanje, mogu izazvati produkciju oksidativnih radikala in vitro, a oni mogu uzrokovati citotoksičnost i genotoksičnost. Najveći broj studija pokazuje da nema značajne resorpcije TiO2 i TiO2 NPs kroz zdravu kožu. Izvršena je analiza podataka o njihovom sadržaju u preparatima za sunčanje na trzištu Srbije. Postoji veliki broj preparata za sunčanje sa različitim SPF (sun protection factor), a najveći broj ima SPF veći od 30. Kod preparata sa SPF većim od 30, najčešći su fizički blokatori (TiO2 i TiO2 NPs) 63%, dok je u preparatima sa SPF manjim od 30, ovaj procenat dvostruko manji. U proizvodima domaćih proizvođača najčešće se nalazi TiO2, za razliku od proizvođača iz Evrope, gde se uglavnom koriste TiO2 NPs. U sredstvima za sunčanje za decu ima najmanje preparata koji sadrže TiO2 NP, što je posebno važno, jer su studije pokazale da je resorpcija nanočestica povećana kroz osetljivu, oštećenu i obolelu kožu.

 

 

Ključne reči:

preparati za sunčanje, TiO2, TiO2 NPs, srpsko tržište

 

 

References:

 

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PDF Kostić E. and Vujović M. • MD-Medical Data 2018;10(4): 173-177