md-medicaldata

Authors

 

Aleksandra Bajec-Opančina¹, Vladan Šubarević¹, Katarina Stanković¹, Mladen Novković¹, Anita Agić², Vladan Đorđević<sup>3,4

1</sup>Institut za majku i dete „Dr Vukan Čupić“ Beograd, Srbija /
Institute For Mother and Child „Dr. Vukan Čupić“, Belgrade, Serbia
²Abela Pharm, Beograd, Srbija / Abela Pharm, Belgrade, Serbia
³Klinika za psihijatrijske bolesti „Dr Laza Lazarević” Beograd, Srbija /
Clinic for Psychiatric Disorders „Dr. Laza Lazarević“, Belgrade, Serbia
⁴Farmaceutsko zdravstveni fakultet, Univerzitet u Travniku, Bosna i Hercegovina
/ Faculty of Pharmacy and Health, University of Travnik, Bosnia and Herzegovina

 

Rad je primljen 01.07.2017. / Prihvaćen 04.07.2017

 

Correspondence to

Dr. Vladan Đorđević, PhD,
Clinic for Psychiatric Disorders
„Dr. Laza Lazarević” Belgrade, Serbia
Faculty of Pharmacy and Health, University of Travnik,
Bosnia and Herzegovina
e-mail: drvladandjordjevic@gmail.com

 

 

Abstract

 

Acute respiratory infections are a very frequent problem in children, especially young ones. In case of the infections of viral origin, the symptomatology is unspecific; therefore, the therapy is symptomatic. Phytotherapy is the comparison of the pharmacological properties of chemical medicines in interaction with herbs and natural products. The modern era brought modern guidelines for herbs testing, which was confirmed by our predecessors’ experience in using herbs for healing and relieving complaints. The aim of this study was to assess the efficiency of propolis and N-acetylcisteine (PropoMucil® syrup and PropoMucil® nasal spray) in children with respiratory infections. The study was conducted during the period January-April 2016 at the Institute for Mother and Child „Dr. Vukan Čupić“ in Belgrade. The study included two groups of children: group A - children with the symptoms of the secretory inflammation of the middle ear and group B - children with the symptoms of the inflamed nasal mucosa. Demographic data and duration of symptoms were recorded for both groups at first examination, while group A was assessed for type of symptoms, otoscopic and tympanometric findings and group B was assessed for endoscopic finding, appearance and microbiological finding of the excretion both at visit one and at the follow-up visit. At follow-up, the children in group A had statistically less infection symptoms, with the normalization of the otoscopic and tympanometric findings. At the repeated examination, the children in group B had statically less infection symptoms, with the normalization of the endoscopic finding, appearance of excretion and microbiological finding.

 

 

 

Key words:

acute respiratory infections, children, propolis, N-acetylcisteine.

 

 

Sažetak

 

Akutne respiratorne infekcije su vrlo čest problem sa kojima se susreću deca, naročito mlađeg uzrasta. Simptomatologija je u slučaju virusnog porekla infekcije nespecifična, pa se je i terapija simptomatska. Fitoterapija predstavlja upoređivanje farmakoloških svojstava hemijskih lekova u interakciji sa biljem i proizvodima iz prirode. Savremeno doba donelo je moderne smernice u ispitivanjima biljaka, što je potvrdilo iskustvo naših predaka u korišćenju bilja pri lečenju i ublažavanju tegoba. Cilj istraživanja bio je da se proceni efikasnost primene propolisa i N-acetilcisteina (PropoMucil® sirupa i PropoMucil® spreja za nos) kod dece sa respiratornim infekcijama. Istraživanje je sprovedeno od januara do aprila 2016. godine u Institutu za majku i dete „Dr Vukan Čupić“ u Beogradu. Istraživanjem su obuhvaćene dve grupe dece: grupa A-deca sa simptomima sekretornog zapaljenja srednjeg uha i gupa B-deca sa simptomima zapaljenja nosne sluznice. U obe grupe dece beleženi su na prvom pregledu demografski podaci, dužina trajanja simptoma, dok su na prvom i kontrolnom pregledu beleženi tipovi simptoma, otoskopski i timpanometrijski nalaz - u grupi A i endoskopski nalaz, izgled sekreta i mikrobiološki nalaz u grupi B. U grupi A dece je pri kontrolnom pregledu statistički bila manje zastupljena simptomatologija infekcije, uz normalizaciju otoskopskog i timpanometrijskog nalaza. U grupi B dece je na ponovnom pregledu statistički bila manje zastupljena simptomatologija infekcije, došlo je do normalizacije endoskopskog nalaza, izgleda sekreta i mikrobiološkog nalaza.

 

 

Ključne reči:

akutne respiratorne infekcije, deca, propolis, N-acetilcistein.

 

 

References

 

1. Bryce J, Boschi-Pinto C, Shibuya K, Black RE. WHO estimates the causes of death in children. Lancet. 2005; 365: 1147-52.
2. Williams BG, Gouws E, Boschi-Pinto C, Bryce J, Dye C. Estimates of world-wide distribution of child deaths from acute respiratory infections. Lancet Infect Dis. 2002; 2: 25-32. 
3. Katić M, Švab I, et al. Familly Medicine. Alfa, Zagreb, 2013.
4. Tregoning JS, Schwarze J. Respiratory viral infections: causes, clinical symptoms, virology, and immunlogy. Clin Microbiol. Rev. 2010; 23(1):74-98.
5. Sa-Nunes A,  Faccioli LH, Sforcin JM. Propolis: lymphocyte proliferation and IFN-γ production. J Ethnopharmacol 2003; 87(1):93-97.
6. Orsatti CL, Missima F,  Pagliarone AC, Sforcin JM. Th1/Th2 cytokines’ expression and production by propolis-treated mice J. Ethnopharmacol 2010; 129(3):314-318.
7. Onlen Y, Tamer C, Oksuz H, Duran N, Altug ME, Yakan S. Comparative trial of different anti-bacterial combinations with propolis and ciprofloxacin on Pseudomonas keratitis in rabbits. Microbiol Res 2007; 162(1):62-68.
8. Nolkemper S, Reochlin J., Sensh KH, Schitzler P. Mechanism of herpes simplex virus type 2 suppression by propolis extracts. Phytomedicine 2010; 17(2): 132–138.
9. Russo A, Longo R, Vanella A. Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin. Fitoterapia 2002; 73 (1):21-29.
10. Nakajima Y, Shimazawa M, Mishima S, Hara H. Water extract of propolis and its main constituents, caffeoylquinic acid derivatives, exert neuroprotective effects via antioxidant actions. Life Sci 2007; 80(4):370-377.
11. Jasprica I, Mornar A, Debeljak Z, Smolcic-Bubalo A, Medic-Saric M, Mayer L, et al. In vivo study of propolis supplementation effects on antioxidative status and red blood cells. J Ethnopharmacol 2007; 110(3):548-554.
12. Khayyal MT, El-Ghazaly MA, El-Khatib AS, Hatem AM, de Vries PJ, El-Shafei S, et al. A clinical pharmacological study of the potential beneficial effects of a propolis food product as an adjuvant in asthmatic patients. Fundam Clin Pharmacol, 2003; 17(1):93-102.
13. Cotgreave IA. N-acetylcysteine: pharmacological consedirations and experimental and clinical applications. Adv Pharmacol 1997; 38:205-227.
14. Poole PJ, Black PN. Preventing exarcerbations of chronic bronchitis and COPD: therapeutic potential of mucolytic agents. Am J Respir Med 2003; 2:367-370.
15. Dales RE, Cakmak S, Brand K, Judek S. Respiratory illness in children attending daycare. Pediatr Pulmonol. 2004; 38(1): 64-9.
16. Nesti MM, Goldbaum M. Infectious diseases and daycare and preschool education. J Pediatr (Rio J). 2007; 83(4): 299-312.
17. Dahl IL, Grufman M, Hellberg C, Krabbe M. Absenteeism because of illness at daycare centers and in three-family systems. Acta Paediatr Scand. 1991; 80(4): 436-45.
18. Wald ER, Guerra N, Byers C. Frequency and severity of infections in day care: three-year follow-up.J Pediatr. 1991; 118(4 Pt 1): 509-14.
19. Školnik-Popović V, Jovančević M. Infekcije dušnih puteva i boravak u kolektivu. Medix 2015; 21 (115/116): 126-130.
20. Almeida C. E, Menezes H. Anti-inflammatory activity of propolis extracts: A review. J. Venom. Anim. Toxins. 2002; 8(2): pp.191-212.
21. Cheng P.C, Wong G. Honey bee products: prospects in medicine. Bee World, 1992, 77: 8-15.       
22. Krol W, Scheller S, Shani J, Pietz G, Czuba Z. Synergistic effect of ethanolic extract of propolis and antibiotics on the growth of Staphylococcus aureus. Arzneim. Forsch., 1993, 43: 607-9.  
23. Eastwood M.A. Interaction of dietary antioxidants in vivo: how fruit and vegetables prevent disease. Quarterly journal of medicine. 1999; 92: 527–530.
24. Hollman P.C, Katan M.B. Health effects and bioavailability of dietary flavonols. Free Radical Research. 1999; 31:S75–S80.
25. E. S. C. O. P. Monographs. "The Scientific Foundation for Herbal Medicinal Products”, ESCOP, the European Scientific Cooperative on Phytotherapy. Argyle house, Gandy Street, UK.  Second Edition.2003:32- 35.
26. Ali Esmail Al-Snafi et al. The Pharmaceutical Importance of Althaea officinalis and Althaea rosea : A Review.  Int J Pharm Tech Res. 2013,5(3): 1387-1385.
27. Fan C, Pacier C, Martirosyan D.  Rose hip (Rosa canina L): A functional food perspective.  Funct Foods Health Disease. 2014; 4(11):493-509.

UDK: 615.324:638.135
615.23-053.2
616.21/.24-002-085-053.2
COBISS.SR-ID 245414412

PDF Bajec-Opančina A. et al • MD-Medical Data 2017;9(3): 149-153