md-medicaldata

Authors

 

Dejan Stojković¹, Nebojša Marić^1,2, Aleksandar Ristanović¹, Nataša Vešović¹, Vanja Kostovski¹, Ljubinko Đenić¹, Aleksandar Nikolić¹, Vlado Cvijanović<sup>1,2

1</sup>Klinika za grudnu hirurgiju, Vojnomedicinska akademija, Beograd
²Medicinski fakultet Vojnomedicinske akademije, Univerzitet odbrane, Beograd

 

The paper was received on 12.02.2017. / Accepted on 22.02.2017

 

Correspondence to

Dejan Stojković
Vojnomedicinska akademija, Crnotravska 17, 11040 Beograd
Tel. 011 266 11 22
e-mail: : dekonja45@yahoo.com

 

 

Abstract

 

Introduction. Extragonadal mediastinal germ tumors are rare, predominantly in young males. They can be bening, mixed, seminoma or nonseminoma germ cell tumors which include also teratoma malignum. Incidence is 3-5%. They are localized in retroperitoneum or mediastinum. Serological markers are high values of alpha-fetoprotein (AFP), human horion gonadotropin (beta- hCG), gamma-glutamin transpherase (gamma-GT) and lactat-dehydrogenasis (LDH). Pathological examination is definitive for confirmation of disease. Main goal of this case report is our experiance in the treatement of this rare entity. Male patient, 37 years was presented. After respiratory symptoms, multislice computed tomography (MSCT) of thorax was made. There was seen tumor mass in front and middle mediastinum. Serological markers were increased. After tru cut needle biopsy, there was pathological confirmation about mixed germ cell tumor which was totaly extirpated after neoadjuvant hemotherapy. Thoracic surgery is a method of choice for treatement of germ mediastinal tumors after neoadjuvant hemotherapy.

 

 

 

Key words:

germ cell tumor, teratoma, mediastinal extragonadal tumor of testis, surgical treatement

 

 

Sažetak

 

Ekstragonadalni germinativni tumori u medijastinumu su prava retkost i javljaju se pretežno kod mlađih muškaraca. Mogu biti benigni, mešoviti, seminomski i neseminomski germinativni tumori kojima pripadaju i maligni teratomi. Prisutni su u 3-5% slučajeva. Kada se jave, lokalizovani su u retroperitoneumu ili medijastinumu. Serološki markeri njihovog pojavljivanja su povećanje vrednosti alfa-fetoproteina (AFP), humanog horionskog gonadotropina (beta-hCG), gama-glutamin-transferaze(gama-GT) i laktat-dehidrogenaze (LDH). Definitivnu potvrdu bolesti daje patohistološka verifikacija tumora. Cilj ovog rada je da se prikaže naše iskustvo u lečenju ovog retkog entiteta. Prikazali smo bolesnika dobi od 37 godina kod koga je zbog respiratornih tegoba učinjena multislajsna kompjuterizovana tomografija (MSCT) grudnog koša na kojoj je uočena tumorska promena u prednjem i srednjem medijastinumu, što je bilo praćeno povećanjem markera u serumu. Nakon učinjene tru cut iglene biopsije, patohistološki je potvrđeno da se radi o mixed germ cell tumoru koji je nakon sprovedene adjuvantne hemoterapije ekstirpiran u celosti. Torako-hirurško lečenje germinativnih tumora medijastinuma je terapija izbora nakon sprovedene neoadjuvantne hemoterapije

 

 

Ključne reči:

tumori germinativnih ćelija, teratom, ekstragonadalni tumor testisa u medijastinumu, hirurško lečenje

 

 

References

 

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PDFStojković D. et al MD-Medical Data 2017;9(2): 113-116