md-medicaldata

Authors

 

¹Marija Živković Radojević, ²Marina Marković, ²Aleksandar Dagović
¹ Fakultet medicinskih nauka Univeziteta u Kragujevcu
² Klinički centar Kragujevac, Centar za onkologiju i radiologiju, Odeljenje hemioterapije

 

• The paper was received on 03.11.2016. / Corrected 12.11.2016 / Accepted on 14.11.2016

 

 

Correspondence to:
dr Marija Živković Radojević, MD, PhD student
Janka Veselinovića 82,
34000 Kragujevac
phone: +381-65/83-84-450
e-mail: e-mail: makizivkovicmarija@gmail.com

 

 

Abstract

 

Cisplatin is one of the most efficient antineoplastic drugs used in the treatment of solid tumors, testicular, head and neck, ovarian, cervical and lung cancer. It's use is often limited by the side effects on the gastrointestinal tract, ototoxicity, nephrotoxicity, neurotoxicity and myelosuppression. Acute kidney damage induced by cisplatin is characterized by a reduction in tubular reabsorption, increase in vascular resistance in the microvasculature of the kidney, increased levels of creatinine and urea in serum, electrolyte imbalance, increase of creatinine clearance and urea, reduced ability to concentrate urine, reduction of glomerular filtration rate, and other parameters. Diagnosis of the kidney damage can not be made at an early stage because the clearance of creatinine little depends on the severity of the damage. By an early identification of risk factors and applying nephroprotective procedures, it is possible to reduce the extent of kidney damage and improve the results of oncological treatment.

 

 

Key words

cisplatin, acute kidney damage, mechanism, diagnosis, prevention

 

 

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PDF Radojević Živković M. et al • MD-Medical Data 2016;8(4): 223-228