md-medicaldata

Authors

 

Marijana Ćurčić¹, Marko Antunović², Maja Džoković³, Saša Janković⁴, Vesna Milovanović⁵, Snežana Đorđević², Vesna Kilibarda², Slavica Vučinić², Biljana Antonijević^1
1 University of Belgrade – Faculty of Pharmacy, Depertment of Toxicology „Akedamik Danilo Soldatović“, Vojvode Stepe 450, 11221 Belgrade, Serbia
² National Poison control center, Military Medical Academy, Crnotravska 17, Belgrade, Serbia
³ Consultant in analytical biochemistry, Belgrade, Serbia
⁴ Institute of Meat Hygiene and Technology, Kacanskog 13, Belgrade, Serbia
⁵ University Childrens Hospital Tiršova, Tiršova 2, Belgrade, Serbia

 

• The paper was received on 01.03.2016. / Accepted on 09.03.2016.

 

 

Abstract

 

It is known that kidneys are target tissue for Cd toxicity but there is not enough literature data on kidney effects of BDE-209.  Moreover, Cd as toxic metal and BDE-209 as organic halogenated pollutant can share similar mechanism of action like, oxidative stress which is already assumed. However, how will Cd act as prooxidant in presence of BDE-209 is still not investigated, therefore, the objective of this study was to assess this BDE-209 influence. Results of this study indicated slight decrease in MDA in rat’s kidney homogenates after subacute exposure to Cd and/or BDE-209, while SOD activity was increased and content of –SH groups decreased. Based on dose-response assessment, BDE-209 did not influence Cd toxicity mediated by chosen oxidative stress parameters, namely the derived CEDL5 values were the same for single Cd and for Cd given in combination with the BDE-209.
In conclusion, dynamic of oxidative process has influence on the parameters levels. Co-exposure with polybrominated organic pollutant did not influence Cd effects on oxidative stress parameters. Having in mind that this is pilot study, performed with only one dose of BDE-209, further investigations are necessary, including changes in dose ranges, duration of exposure etc. Moreover, results contributes to the issue of mixture toxicology even BDE-209 did not influenced oxidative stress as mechanism of Cd toxicity.

 

 

Key words

cadmium, decabromiated diphenyl ether (DBE-209), oxidative stress

 

 

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