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TALOŽENJE ARSENA U ORGANIMA EKSPERIMENTALNOG MODELA MUŽJAKA MIŠEVA EKSPONIRANIH MAKSIMALNOJ KONCENTRACIJI EKVIVALENTNOJ U VODOVODNOJ MREŽI BANATA /

DEPOSITION OF ARSENIC IN THE ORGANS OF AN EXPERIMENTAL MODEL OF MALE MICE EXPOSED TO THE MAXIMUM CONCENTRATION EQUIVALENT TO THE WATER SUPPLY NETWORK OF BANAT

Authors

 

Anita Birinji1, Željko Mihaljev2, Dušan Lalošević3, Marija Marin1

1Univerzitet u Beogradu, Biološki fakultet, Studentski trg 16, 11000 Beograd
2Naučni institut za veterinarstvo ,,Novi Sad”, Rumenački put 20, 21113 Novi Sad, Srbija
3Univerzitet u Novom Sadu, Medicinski fakultet i Pasterov zavod Novi Sad, Hajduk Veljkova 1, 21000 Novi Sad, Srbija

 

UDK: 615.9:546.19
616-099:546.19


The paper was received / Rad primljen: 01.12.2021.

Accepted / Rad prihvaćen: 01.06.2022.

 


Correspondence to:


Birinji Anita
e-mail: ani.birinji@gmail.com

 

 

Sažetak

 

 

Prisustvo arsena u životnoj sredini predstavlja ozbiljan zdravstveni problem. Na teritoriji Srbije najviše je prisutan u Vojvodini. Postavili smo eksperimentalni model izloženosti arsena u vodi za piće kroz tri generacije miševa. Koncentracija arsena je određena prema formuli za preračunavanje vrednosti kojima mogu biti izloženi ljudi u vodovodu Banata na animalni model. Postavljene su dve grupe miševa eksponiranih arsen (III)-oksidu od 10,6 mg/L i deset puta veća, 106 mg/L. U radu su prikazani rezultati sadržaja ukupnog arsena deponovanog u organima mužjaka miševa (jetra, bubrezi, testisi, mozak) praćeni kroz tri uzastopne generacije. Rezultati ukazuju da se arsen taloži u organima i da sadržaj ukupnog arsena tokom generacija ne opada. Nisu registrovane promene u aktivnosti miševa, ishrani, ni većem gubitku telesne težine. Nema registrovanih tumoroznih promena na spoljašnjoj i unutrašnjoj građi tela. Nisu zabeležena masovna uginuća životinja tokom ogleda.

 

 

 

Ključne reči:

arsen(III)-oksid, miševi, eksperimentalni model.

 

 

 

Abstract


The presence of arsenic in the environment is a serious health problem. On the territory of Serbia, it is most present in Vojvodina. We set up an experimental model of arsenic exposure in drinking water through three generations of mice. The concentration of arsenic was determined according to the formula for converting the values to which people can be exposed in the Banat water supply system to the animal model. Two groups of mice exposed to arsenic (III)-oxide of 10.6 mg/L and ten times higher, 106 mg/L, were placed. The paper presents the results of the content of total arsenic deposited in the organs of male mice (liver, kidneys, testicles, brain) followed through three consecutive generations. The results indicate that arsenic is deposited in organs and that the content of total arsenic does not decrease over generations. No changes were registered in the mice's activity, diet, or significant loss of body weight. There are no registered tumorous changes on the external and internal structure of the body. No mass deaths of animals were recorded during the experiment.

 

 


Key words:

arsenic(III)-oxide, mice, experimental model.

 

 

 

 

References:

  1. Mandal BK, Ogra Y, Anzai K, Suzuki KT. Speciation of arsenic in biological samples. Toxicol Appl Pharmacol 2004; 198: 307-18.
    Kristoforović-Ilić M. Arsenic. Medicinski Pregled 2004,57 (7-8), 319-322.
    1. Jovanović B, Ljubisavljević D, Rajaković Lj. Uklanjanje arsena iz vode adsorpcijom na nekonvencionalnim materijalima. Vodoprivreda 2011, 43 (252-254): 127-150.
    2. Kitchin KT. Recent research in arsenic carcinogenesis: modes of action, animal model system, and methylated arsenic metabolites. Toxicol Appl Pharmacol 2001; 172: 249-61.
    3. Duker AA, Carranza EJM, Hale M. Arsenic geochemistry and health. Environ Internat 2005; 31: 631-41.
    4. Nandi D, Patra RC, Swarup D. Effect of cysteine, methionine, ascorbic acid and thiamine on arsenic-induced oxidative stress and biochemical alterations in rats. Toxicology 2005; 211: 26–35.
    5. Kapaj S, Peterson H, Liber K, Bhattacharya P. Human health effects from chronic arsenic poisoning – a review. J. Environ Sci Health A Tox Hazard Subst Environ Eng 2006; 41: 2399-428.
    6. Guha Mazumder DN. Chronic arsenic toxicity: clinical features, epidemiology, and treatment: experience in West Bengal. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2003;38(1):141-63.
    7. Longnecker MP, Danials JL. Environmental contaminations as etiologic factors for diabetes. Environ Health Perspect 2001; 69: 871-6.
    8. Tseng CH, Tai TY, Chong CK, Tseng CP, Lai MS, Lin BJ, et al. Long-term arsenic exposure and incidence of non-insulin-dependent diabetes mellitus: a cohort study in arseniasis-hyperendemic villages in Taiwan. Environ Health Perspect 2000; 108: 847-51.
    9. Tseng CH, Tseng CP, Chiou HY, Hsueh YM, Chong CK, Chen CJ. Epidemiologic evidence of diabetogenic effect of arsenic. Toxicol Lett 2002; 133: 69-76.
    10. Rahman M, Tondel M, Ahmad SA, Axelson O. Diabetes mellitus associated with arsenic exposure in Bangladesh. Am J Epidemiol 1998; 148: 198-203.
    11. Del Razo LM, Styblo M, Cullen WR, Thomas DJ. Determination of trivalent methylated arsenicals in biological matrices. Toxicol Appl Pharmacol 2001; 174: 282-93.
    12. Borzsonyi M, Bereczky A, Rudnai P, Scanady M, Horvath A. Epidemiological studies on human subjects exposed to arsenic in drinking water in Southeast Hungary. Arch Toxicol 1992; 66: 77-8.
    13. Hopenhayn-Rich C, Browning SR, Hertz-Picciotto I, Ferrsccio C, Peralta C, Gibb H. Chronic arsenic exposure and risk of infant mortality in two areas of Chile. Environ Health Perspect 2000; 108: 667-73.
    14. Singh N, Kumar D, Sabu AP. Arsenic in the environment: effects on human healthand possible prevention. J Environ Biol 2007; 28: 359-65.
    15. ATSDR (Agency for Toxic Substances and Disease Registry) 2005; Toxicological profile for arsenic. Draft for public comment. Update. US Department of Health and Human Services, Public Health Service
    16. Cohen SM, Arnold LL, Eldan M, Lewis AS, Beck BD. Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment. Crit. Rev.Toxicol. 2006,36(2), 99–133.
    17. Nair A.B., Jacob S. A simple practice guide for dose conversion between animals and human. Journal of Basic and Clinical Pharmacy 2016; 7: 27-31.
    18. Nelms S. (Ed.) 2005. Inductively coupled plasma mass spectrometry handbook. Blackwell Publishing, pp. 504.

PDFBirinji A. et al. MD-Medical Data 2022;14(1-2): 041-044

 

 

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