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PATOHISTOLOŠKE KARAKTERISTIKE KOŠTANE SRŽI ZAHVAĆENE LIMFOMIMA /

PATHOHISTOLOGICAL CHARACTERISTICS OF BONE MARROW INVOLVED BY LYMPHOMAS

Authors

 

Dimitrije Stevanović 1,2, Tanja Lakić1,2

1Univerzitetski klinički centar Vojvodine, Centar za patologiju i histologiju, Novi Sad, Srbija
2Medicinski fakultet, Univerzitet u Novom Sadu, Novi Sad, Srbija

 

UDK: 616-006.44-074
616.419-076


The paper was received / Rad primljen: 21.12.2022.

Accepted / Rad prihvaćen: 21.02.2022.

 


Correspondence to:


Dimitrije Stevanović
Fruškogorskog odreda 8,
21132 Petrovaradin, Srbija
+381631658788
e-mail: nsdimitrije@gmail.com

 

 

Sažetak

 

Uvod: Razvoj novih metoda dijagnostike limfoma, u nekim zemljama polako potiskuje potrebu za biopsijom koštane srži, te je neophodno kontinuirano unapređivanje znanja o dijagnostičkim metodama, ne bi li se značaj istih potvrdio ili opovrgao. Materijal i metode: Retrospektivno je izvršena analiza patohistoloških izveštaja bolesnika kojima je tokom 2019. i 2020. godine u Centru za patologiju i histologiju Univerzitetskog kliničkog centra Vojvodine u Novom Sadu patohistološki verifikovana infiltracija koštane srži primarnim limfomom. Rezultati: Ukupno je registrovano 75 ispitanika, prosečne starosti 58 godina, pri čemu su 44% činili muškarci, a 56% žene. Izuzimajući HLL/SLL, najčešći limfomi su bili „mantle cell“ i limfomi marginalne zone. „Mantle cell“ limfom je bio češći kod muškaraca, dok su u ženskoj populaciji frekventniji bili difuzni krupnoćelijski, sitnoćelijski limfocitni i limfom marginalne zone. Prosečna celularnost koštane srži iznosila je 61,47%, dok je prosečna zahvaćenost koštane srži atipičnim limfoidnim infiltratom iznosila 37%. Zaključak: Koštana srž zahvaćena limfomima je u većini slučajeva hipercelularna ili normalne celularnosti u odnosu na starost ispitanika, prosečne infiltracije 37%, retikularne osnove gradusa II, sa različitom polnom predominacijom u zavisnosti od patohistološkog tipa.

 

 

 

Ključne reči:

limfomi; infiltracija; biopsija

 

 

 

Abstract


Introduction: In some countries, development of new diagnostic methods for the lymphoma diagnosis is slowly suppressing the need for bone marrow biopsy and it is necessary to continuously improve knowledge about diagnostic methods, in order to confirm or refute the importance of them. Materials and methods: Retrospectively, we analyzed bone marrow biopsy reports from patients who had infiltration of bone marrow by lymphoma during years 2019-2020. All cases were diagnosed in the Center for pathology and histology of the University Clinical Center of Vojvodina, in Novi Sad. Results: Diagnosis was pathohistologically verified in 75 cases, with female predominance - 44% were males and 56% were females with average age of 58 years. Except CLL/SLL, most common lymphomas involving bone marrow were „mantle cell“ and marginal zone lymphomas. „Mantle cell“ lymphomas were more common in males, whereas small lymphocytic, diffuse large B-cell and marginal zone lymphomas affected female patients more. Average bone marrow cellularity was 61.47% and percentage of tumor infiltration averaged at 37%. Conclusion: According to age, bone marrow involved by lymphomas was in most cases hypercellular or normocellular, with average infiltration of 37%, grade II reticular fibrosis and different gender disparity depending on pathohistologycal lymphoma type.

 

 


Keywords:

lymphoma; infiltration; biopsy

 

 

 

 

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PDFStevanović D. et al MD-Medical Data 2022;14(1-2) 013-017

 

 

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