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ALBUMIN TO GLOBULIN RATIO AS A BIOMARKER IN MALIGNANT DISEASE; A CLINICAL SIGNIFICANCE AND PRACTICAL APPLICATION /

ALBUMIN-GLOBULIN ODNOS KAO BIOMARKER U MALIGNIM BOLESTIMA; KLINIČKI ZNAČAJ I PRAKTIČNA PRIMENA

Authors

 

Dejana Bajić1, Andrea Zubnar2, Dragica Bulajić3, Nemanja Todorović4, Ivana Isakov 5

1University of Novi Sad, Faculty of Medicine, Department of Biochemistry Novi Sad, Serbia
2University of Novi Sad, Faculty of Medicine, Department of Physiology, Novi Sad, Serbia
3University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia
4University of Novi Sad, Faculty of Medicine, Department of Pharmacy, Novi Sad, Serbia
5Clinical Center of Vojvodina, Center for Laboratory Medicine, Novi Sad, Serbia

 

UDK: 616-083-053.2


The paper was received / Rad primljen: 18.02.2021.

Accepted / Rad prihvaćen: 18.03.2021.

 


Correspondence to:


Dejana Bajić, Doctor of Medicine
Teaching Assistant at Department of Biochemistry,
University of Novi Sad, Faculty of Medicine,
Department of Biochemistry,
Hajduk Veljkova 3,
21 137 Novi Sad, Serbia
Phone number: +381606330-550
e-mail: dejana.bajic@mf.uns.ac.rs

 

 

Abstract

 

 

Introduction: The prognostic markers for human cancers are numerous, mostly are expensive or cannot be obtained before treatments. Albumin and globulin are two major components of human serum and they have been concerned as noninvasive prognostic factors in various malignancies. Serum biochemical parameter-the pretreatment albumin to globulin ratio (AGR) has been commonly considered to be a reliable biomarker. Topic: The discovery of biological markers, which can predict the risk of metastasis and mortality to assist with clinical decision-making, is still a major topic. Recent studies have shown that albumin to globulin ratio is widely used as a prognostic biomarker in diverse cancers. Reference value forAGR is ususally between 1,0 and 1,8 in a healthy population. A low AGR indicate increased production of globulins or insufficient synthesis of albumin in patients with cancer. A decreased albumin level and an increased globulin level are part of chronic inflammation which support tumor development. Albumin and globulin have a strong impact oninflammation and immunity of host. Conclusion: Diverse researches analyzed the clinical significance of pretreatment AGR and its potential contribution to the prognosis of cancer. Results indicated that a low AGR was associated with adverse clinical outcome and poor survival. AGR is considered to be an optimal prognostic marker than the single serum albumin or globulin levels.

 

 

 

Keywords:

albumin to globulin ratio, biomarker, prognostic marker

 

 

 

Sažetak


Uvod: Za procenu ishoda lečenja tumora koriste se brojni prognostički biomarkeri. Nedostatak većine markera je što se ne mogu primeniti pre započetog lečenja ili što zbog svoje vrednosti predstavljaju značajan trošak za zdravstveni sistem.Albumini i globulini su glavne komponenete serumskih proteina i razmatrani su kao neinvazivni prognostički faktori u brojnim malignitetima. Biohemijski parametar- albumin globulin odnos (AGR) se smatra pouzdanim biomarkerom. Tema: Jedna od vodećih tema je otkrivanje  relevantnih biomarkera koji mogu predvideti rizik od metastaza i mortaliteta  prilikom odabira odgovarajućih terapijskih protokola. Nedavno su studije pokazale da se albumin/globulin odnos koristio kao prognostički biomarker kod pacijenata sa različitim vrstama tumora. Kod zdravih osoba AGR odnos se nalazi u rasponu od 1,0 do 1,8. Nizak AGR može biti odraz prekomerne produkcije globulina ili smanjene sinteze albumina kod pacijenata obolelih od kancera. Obe pojave reflektuju hroničnu inflamaciju koja pogoduje progresiji tumora, težim oblicima bolesti, lošijoj prognozi i kraćem vremenu preživljavanja. Albumini i globulini igraju značajnu ulogu u imunitetu iinflamatornim procesima koji su usko povezani sa nastankom i razvojem tumora u organizmu. Zaključak: U okviru različitih istraživanja prikazan je klinički značaj AGR pre započetog terapijskog protokola u vidu potencijnog doprinosa prognozi različitih vrsta tumora. Rezultati su ukazivali da je nizak AGR povezan sa lošijom kliničkom slikom i slabijim ukupnim preživljavanjem.U odnosu na pojedinačne vrednosti albumina ili globulina, AGR kao prognostički biomarker se  smatra boljim pokazateljem dugoročne prognoze kod obolelih od malignih bolesti.

 

 


Ključne reči:

albumin/globulin odnos, biomarker, prognostički marker

 

 

 

 

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PDF06-MD-Vol 13 No 1 2021_Bajić et al.

 

 

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