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DŽINOVSKI TUMOR NEODREĐENOG MALIGNOG POTENCIJALA POREKLA GLATKOG MIŠIĆNOG TKIVA LOKALIZOVAN U CERVIKSU I ISTMUSU MATERICE /

GIANT SMOOTH MUSCLE TUMOR OF UNCERTAIN MALIGNANT POTENTIAL OF UTERINE CERVIX AND ISTHMUS

Authors

 

Milan Popović1,2, Zoran Nikin2,3, Goran Malenković4,5, Nevena Stanulović2,3, Tatjana Ivković-Kapicl2,3

1Univerzitet u Novom Sadu, Medicinski fakultet, Katedra za histologiju i embriologiju
2Institut za onkologiju Vojvodine, Služba za patološko-anatomsku i laboratorijsku dijagnostiku, Sremska Kamenica, Srbija
3Univerzitet u Novom Sadu, Medicinski fakultet, Katedra za patologiju
4Univerzitet u Novom Sadu, Medicinski fakultet, Katedra za zdravstvenu negu
5Institut za onkologiju Vojvodine, Klinika za operativnu onkologiju, Sremska Kamenica, Srbija

 

UDK: 618.14-006


The paper was received / Rad primljen: 29.12.2020.

Accepted / Rad prihvaćen: 31.12.2020.

 


Correspondence to:


dr Milan Popović
Katedra za histologiju i embriologiju
Medicinski fakultet, Univerzitet u Novom Sadu
Hajduk Veljkova 3, 21 000 Novi Sad
Hajduk Veljkova 3, 21 000 Novi Sad
e-mail: milan.popovic@mf.uns.ac.rs

 

 

Sažetak


Pacijentkinja, 48 godina starosti, na CT snimku abdomena i male karlice ima tumorsku masu na uterusu dimenzija 29x22x32 cm koja ispunjava celu malu karlicu i abdomen, do 3 prsta iznad umbilikusa koja datira od pre 2 godine. Nakon izvršene totalne histerektomije patohistološkom analizom nadjena je ovalna tumorska tvorevina mase 9750 g i dimenzija 36 x 25 x 20 cm koja u potpunosti zauzima stromu cerviksa i istmus materice. Raspoznatljivi deo tela materice je dimenzija 7,5 x 7 x 3,5 cm, a prečnik vaginalne porcije grlića 8,5 cm. Tumorsko tkivo je sagrađeno od snopova izduženih mišičnih vlakana uobičajenog izgleda, dok je delom miksoidno izmenjeno, sa znacima blage do umerene atipije. Mitotska aktivnost je slabo naglašena (1 mitoza na 10 vidnih polja velikog uveličanja). Na osnovu histomorfoloških karakteristika nalaz odgovara minimalno atipičnoj glatkomišićnoj neolazmi niskog mitotskog indeksa (engl. Smooth muscle tumor of uncertain malignant potential - STUMP).


Ključne reči:

materica, neoplazma porekla glatkog mišinog tkiva, STUMP

 

Abstract


A 48-year-old patient, on a CT scan of the abdomen and small pelvis, has a tumor mass on the uterus measuring 29x22x32 cm that fills the entire small pelvis and abdomen, up to 3 fingers above the umbilicus dating from 2 years ago. After a total hysterectomy, pathohistological analysis revealed an oval tumor weighing 9750 g and measuring 36 x 25 x 20 cm, which completely occupies the stroma of the cervix and the isthmus of the uterus. The recognizable part of the body of the uterus is 7.5 x 7 x 3.5 cm, and the diameter of the vaginal portion of the cervix is 8.5 cm. Tumor tissue is composed of bundles of elongated muscle fibers of normal appearance, while it is partly myxoid-altered, with signs of mild to moderate atypia. Mitotic activity is weakly emphasized (1 mitosis per 10 high magnification visual fields). Based on histomorphological characteristics, the finding corresponds to a minimally atypical smooth muscle neoplasm of low mitotic index, the smooth muscle tumor of uncertain malignant potential – STUMP.


Key words:

uterus, smooth muscle neoplasm, STUMP

 

 

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PDF 08-Vol 12 No4 Popovic

 

 

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