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SECONDARY ANGIOSARCOMA AS A COMPLICATION OF RADIOTHERAPY OF THE BREAST CARCINOMA: 3 CASES REPORT AND LITERATURE REVIEW /
SEKUNDARNI ANGIOSARKOM KAO KOMPLIKACIJA RADIOTERAPIJE KARCINOMA DOJKE: PRIKAZ 3 SLUČAJA I PREGLED LITERATURE

Authors

 

Nevena Stanulović 1 , Tatjana Ivković Kapicl 1,2, Ferenc Vicko1,3, Milan Popović1,4

1Oncology Institute of Vojvodina, Sremska Kamenica
2University of Novi Sad, Faculty of Medicine, Department of Pathology
3University of Novi Sad, Faculty of Medicine, Department of Surgery 4University of Novi Sad, Faculty of Medicine, Department of Histology and Embryology

 

UDK: 616-006.3-02 618.19-006:615.849


The paper was received / Rad primljen: 01.03.2020.

Accepted / Rad prihvaćen: 23.03.2020.

 


Correspondence to:


Tatjana Ivković Kapicl, MD, PhD
Department of Pathology, Faculty of Medicine, Univerisity of Novi Sad
Hajduk Veljkova 3, 21000 Novi Sad
Tel: +381 640128043096
e-mail: tatjana.ivkovic-kapicl@mf.uns.ac.rs

 

 

Abstract

 

Introduction: Angiosarcomas are aggressive malignant neoplasm of vascular endothelial origin most frequently compelling the skin. Secondary angiosarcoma of the breast or a cheast wall,  is a late and rare sequela of radiotherapy for breast carcinoma after radical of breast conserving surgery. Case presentation: We report 3 cases of patients who initially underwent conserving surgical treatment of primary breast cancer, followed by adjuvant chemo- and radiotherapy. Seven years in first, and five years in other two cases, after initial treatment, all patient presented with painless, colored skin lesions, in area of surgical scar. Biopsy of these lesions revealed diagnosis of angiosarcoma. Shortly afterward, despite radical excision followed by adjuvant chemotherapy, two reported patients developed local recidivies and distant metastases. Conclusion: Due to unspecific behavior of secondary angiosarcoma of the breast, and a great potential for local recurrence, the extra caution should be paid in order to prevent the substantial time delay between final diagnosis and treatment of the secondary angiosarcoma of the breast.

 

Key words:

radiation-induced angiosarcoma, radiotherapy, breast cancer

 

 

Sažetak

 

Uvod: Angiosarkomi su agresivne neoplazme porekla krvnih sudova koje najčešće zahvataju kožu. Sekundarni angiosarkom je retka i kasna komplikacija zračne terapije nakon poštedne operacije karcinoma dojke. Prikaz slučajeva: Prikazali smo tri slučaja pacijentkinja koje su inicijalno podvrgnute poštednoj operaciji primarnog karcinoma dojke, praćenim adjuvantnom hemio- i zračnom terapijom. Sedam godina u prvom, I pet godina u druga dva slučaja, nakon inicijalnog tretmana, sve pacijentkinje se javljaju se sa nalazom palpabilnih, bezbolnih, tamnije prebojenih promena kože dojke, u regiji prethodno operisanog karcinoma. Biopsijom uočenih promena postavlja se dijagnoza angiosarkomaUprkos radikalnoj eksciziji praćenoj adjuvantnom hemioterapijom, kod dva prikazana slučja razvili su se lokalni recidivi i udaljene metastaze. Zaključak:. Usled nespecifične prezentacije sekundarnog angiosarkoma dojke, i velike verovatnoće nastanka lokalnog recidiva, potreban je dodatan oprez kako bi se sprečilo odlaganje postavljanja defintivne dijagnoze a sasim tim i terapijskog tretmana.

 

 

Ključne reči:

angiosarkom, karcinom dojke,  radioterapija

 

 

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PDF Stanulović N. et al • MD-Medical Data 2020;12(1): 049-052

 

 

 

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