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THE ROLE OF PATHOHISTOLOGICAL AND MICROBIOLOGICAL DIAGNOSIS IN LUNG DISEASES CAUSED BY ASPERGILLUS SPECIES /
ULOGA PATOHISTOLOŠKE I MIKROBIOLOŠKE DIJAGNOZE U PLUĆNIM OBLICIMA BOLESTI IZAZVANIM GLJIVICAMA IZ RODA ASPERGILLUS

Authors

 

Željka Vrekić1, Aleksandra Lovrenski2,3, Dragana Tegeltija2,3, Slađana Novković Ostojić3, Bosiljka Krajnović4, Anika Považan2,3

1Center for Pathology and Histology, Clinical Center of Vojvodina, Novi Sad, Serbia
2Faculty of Medicine Novi Sad, University of Novi Sad, Serbia
3Institute for pulmonary diseases of Vojvodina, Sremska Kamenica, Serbia
4General Hospital of Kikinda, Serbia

 

UDK: 616.24-002.828-07


The paper was received / Rad primljen: 20.06.2019.

Accepted / Rad prihvaćen: 27.06.2019

 


Autor za korespondenciju:


Željka Vrekić, MD
Center for Pathology and Histology, Clinical Center of Vojvodina, Novi Sad, Serbia
Hajduk Veljkova 3, 21000 Novi Sad, Serbia
Mobile phone: +381 64 394 3768
e-mail: zeljkavrekic@hotmail.com

 

 

Abstract

 

Introduction: Aspergillus species can cause a wide range of lung diseases, depending on the current state of immunity and the existing pulmonary diseases. The most common manifestations of lung diseases are aspergilloma, allergic bronchopulmonary aspergillosis, invasive pulmonary aspergillosis and chronic necrotizing pulmonary aspergillosis.  Material and Methods: This prospective study included 26 patients with proven Aspergillus species infection during the period from January 2015. until December 2016.
Results: Aspergilloma was diagnosed at 23 (88.5%) patients. At 2 (7.7%) patients chronic necrotizing aspergillosis was determined, and at 1 (3.8%) patient invasive aspergillosis was diagnosed. By pathohistological analysis, the presence of Aspergillus was detected at 16 (61.5%) patients, and at 10 (38.5%) patients by microbiological diagnosis. At two patients (7.7%) Aspergillus was confirmed both pathohistologically and microbiologically. Conclusion: Since the diagnosis of diseases caused by Aspergillus species is demanding, with characteristic clinical and radiological findings, a laboratory confirmation of the fungus is essential for the final diagnosis.

 

 

Key words:

Lung disease, laboratory diagnosis, aspergillosis, pathohistological finding, microbiological analysis

 

 

 

Sažetak

 

Uvod: Aspergillus species može da izazove čitav spektar plućnih bolesti u zavisnosti od stanja imuniteta i postojećih plućnih oboljenja. Najčešće manifestacije plućnih bolesti su: aspergilom, alergijska bronhopulmonalna aspergiloza, invazivna plućna aspergiloza i hronična nekrotizirajuća plućna aspergiloza. Materijal i metode: Ova prospektivna studija obuhvatila je 26 pacijenata sa dokazanom infekcijom Aspergillus species u periodu od januara 2015. do decembra 2016. godine. Rezultati: Aspergilom je dijagnostikovan kod 23 (88,5%) pacijenata. Kod 2 (7,7%) pacijenta utvrđena je hronična nekrotizirajuća, a kod 1 (3,8%) invazivna aspergiloza. Patohistološkom analizom, prisustvo aspergilusa dokazano je kod 16 (61,5%) pacijenata, a mikrobiološkom kod 10 (38,5%) pacijenata. Kod dva (7,7%) pacijenta aspergilus je dokazan i patohistološki i mikrobiološki. Zaključak: S obzirom da je dijagnostika oboljenja izazvanih Aspergillus species zahtevna, uz karakterističan klinički i radiološki nalaz, neophodna je laboratorijska potvrda uzročnika za konačno postavljanje dijagnoze.

 

 

Ključne reči:

plućna bolest, laboratorijska dijagnoza, aspergiloza, patohistološki nalaz, mikrobiološka analiza

 

 

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PDF Vrekić Ž. et al. • MD-Medical Data 2019;11(2): 093-097

 

 

 

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