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ULOGA POLIMORFIZMA RS6265 GENA ZA MOŽDANI NEUROTROFNI FAKTOR (BDNF) U RAZVOJU KLINIČKE DEPRESIJE/

THE ROLE OF THE BRAIN-DERIVED NEUROTROPHIC FACTOR GENE RS6265 POLYMORPHISM (BDNF) IN DEVELOPMENT OF MAJOR DEPRESSIVE DISORDER

Authors

 

Aleksandra Milutinović1, Nataša Vučinić2, Biljana Božin2, Vojislava Bugarski Ignjatović3, Snežana Smederevac4, Iva Barjaktarović5, Jovana Drljača6

1Departman za biologiju i ekologiju, Prirodno-matematički fakultet, Univerzitet u Novom Sadu
2Katedra za farmaciju, Medicinski fakultet, Univerzitet u Novom Sadu
3Katedra za psihologiju, Medicinski fakultet, Univerzitet u Novom Sadu
4Odsek za psihologiju, Filozofski fakultet, Univerzitet u Novom Sadu
5Katedra opšteobrazovnih predmeta, Medicinski fakultet, Univerzitet u Novom Sadu
6Medicinski fakultet, Univerzitet u Novom Sadu

 

UDK: 616.89-008.454:575


The paper was received / Rad primljen: 25.02.2019.

Accepted / Rad prihvaćen: 06.03.2019.

 


Correspondence to:


doc. dr Nataša Vučinić,
Katedra za farmaciju,
Medicinski fakultet
Univerzitet u Novom Sadu
Hajduk Veljkova 3, 21000 Novi Sad, Srbija
e-mail: natasa.vucinic@mf.uns.ac.rs

 

 

Sažetak

 

Moždani neurotrofni faktor (BDNF) spada u proteinsku familiju neurotrofina i smatra se da je uključen u genezu određenih poremećaja raspoloženja. Polimorfizam rs6265 (Val66Met) doveden je u vezu sa kliničkom depresijom (MDD) i postoji veliki broj studija koje su ispitale ovaj odnos. Međutim, i posle mnogo godina istraživanja nije moguće utvrditi tačnu ulogu ovog polimorfizma kod MDD, te i danas ostaje otvoreno pitanje da li veza uopšte postoji i ako postoji da li je ovaj polimorfizam odgovaran za razvoj MDD ili samo njenih simptoma. Potrebno je sprovesti dalja i opsežnija istraživanja veze polimorfizma rs6265 i MDD.

 

 

Ključne reči:

moždani neurotrofni faktor, BDNF, klinička depresija, biomarker, rs6265, bihejvioralna genetika.

 

 

Abstract

 

Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin protein family and is considered to be involved in genesis of some mood disorders. Polymorphism rs6265 (Val66Met) is reported to be connected with major depressive disorder (MDD) and there is a large number of scientific papers which analyzed this connection. However, even after many years of investigation it is not possible to determine the exact role of this polymorphism in MDD, so the question if a connection between this polymorphism and MDD even exists still remains unanswered and if it exists, it is unclear whether this polymorphism entails a state marker or a trait marker. It is necessary to carry out further research related to the connection of polymorphism rs6265 and MDD.

 

Key words:

brain-derived neurotrophic factor, BDNF, major depressive disorder, biomarker, rs6265, behavioral genetics

 

 

 

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