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FARMAKOGENETSKI ZNAČAJ MUTACIJA GENA ZA RECEPTOR EPIDERMALNOG FAKTORA RASTA U ĆELIJAMA NESITNOĆELIJSKOG KARCINOMA PLUĆA/

PHARMACOGENETIC SIGNIFICANCE OF EPIDERMAL GROWTH FACTOR RECEPTOR GENE MUTATIONS IN NON-SMALL CELL LUNG CARCINOMA

Authors

 

Jovana Drljača1, Nebojša Janjić1, Nataša Vučinić2, Aleksandra Milutinović3, Milan Popović4, Ivan Čapo4, Slobodan Sekulić5

1Univerzitet u Novom Sadu, Medicinski fakultet Novi Sad
2Univerzitet u Novom Sadu, Medicinski fakultet Novi Sad, Katedra za farmaciju
3Univerzitet u Novom Sadu, Prirodno-matematički fakultet, Departman za biologiju i ekologiju
4Univerzitet u Novom Sadu, Medicinski fakultet Novi Sad, Katedra za histologiju i embriologiju
5Univerzitet u Novom Sadu, Medicinski fakultet Novi Sad, Katedra za neurologiju

 

UDK: 616.24-006-085


The paper was received / Rad primljen: 12.02.2019.

Accepted / Rad prihvaćen: 21.02.2019.

 


Correspondence to:


Jovana Drljača
University of Novi Sad, Faculty of Medicine,
Hajduk Veljkova 3, 21000 Novi Sad, Serbia,
e-mail: jovana.drljaca@uns.ac.rs

 

 

Sažetak

 

Najčešći tip maligniteta na svetskom nivou jeste karcinom pluća, pri čemu se u većini slučajeva radi o nesitnoćelijskom karcinomu pluća (NSCLC), koji je ujedno i najčešći tip karcinoma pluća kod nepušača. Kod većine pacijenata obolelih od NSCLC, ustanovljeno je prisustvo mutacija u genu za receptor epidermalnog faktora rasta (EGFR). Pored hemioterapije, razvijeno je tri generacije lekova - inhibitora tirozin-kinaza (TKI), koji uspešno deluju pri lečenju NSCLC. Međutim, do danas nije otkriven lek koji je u potpunosti efikasan, s obzirom na pojavu rezistencije kod pacijenata. Bez obzira na veliki broj sprovedenih istraživanja, i dalje postoji velika potreba za istraživanjima koja će se fokusirati na molekularnu osnovu NSCLC povezanog sa EGFR mutacijama.

 

 

Ključne reči:

nesitnoćelijski karcinom pluća, farmakogenetika, receptor epidermalnog faktora rasta, EGFR, pokretačke mutacije

 

 

Abstract

 

Lung cancer is the most common malignant disease worldwide. Non small cell lung carcinoma (NSCLC) is present in the majority of cases and also represents the most common type of lung cancer in non-smokers. Mutations in epidermal growth factor receptor gene (EGFR) are found in most patients diagnosed with NSCLC. Besides chemotherapy, three generations of drugs tyrosine-kinase inhibitors (TKIs) are developed and they have made a success in the treatment of NSCLC. However, up to now no drug was found to be fully efficient due to the constant development of resistance in patients. Despite the great number of conducted studies, there is still a need for further research which will focus on molecular basis of NSCLC associated with EGFR mutations.

 

Key words:

non-small cell lung carcinoma, pharmacogenetics, epidermal growth factor receptor, EGFR, driver mutations

 

 

 

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PDF Drljača J. et al. • MD-Medical Data 2019;11(1): 035-041

 

 

 

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