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KARCINOM MOKRAĆNE BEŠIKE: EPIDEMIOLOGIJA I FAKTORI RIZIKA /
URINARY BLADDER CANCER: EPIDEMIOLOGY AND RISK FACTORS

Authors

 

Marko Antunović1,2, Marijana Ćurčić3, Predrag Aleksić4,2, Vladimir Bančević4,2, Snežana Đorđević1,2

1 Nacionalni centar za kontrolu trovanja, Vojnomedicinska akademija, Beograd, Srbija
2 Medicinski fakultet, Vojnomedicinska akademija, Univerzitet odbrane, Beograd, Srbija
3 Univerzitet u Beogradu, Farmaceutski fakultet, Katedra za toksikologiju "Akademik Danilo Soldatović", Beograd ,Srbija
4 Klinika za urologiju, Vojnomedicinska akademija, Beograd, Srbija

 

UDK: 616.62-006.6-02


The paper recieved / Rad primljen: 02.06.2018.

Accepted / Rad prihvaćen: 15.06.2018.

 


Corresponding to:


Marko Antunović
Nacionalni centar za kontrolu trovanja
Vojnomedicinska akademija, Crnotravska 17,
11 000 Beograd, Srbija
e-mail: antunovic.marko87@gmail.com

 

Sažetak

 

Karcinom bešike spada u najčešće tumore mokraćnih organa i čest je uzrok mortaliteta i morbiditeta u celom svetu. Može se pojaviti u bilo kom uzrastu, ali najčešće se javlja kod sredovečnih i starijih pacijenata muškog pola. Najviše stope oboljevanja navode se u razvijenim zemljama Evrope, Severne Amerike i u Australiji. Kao i sve druge maligne bolesti, karcinom bešike se javlja kao posledica interakcije genetskih i sredinskih faktora. Jedan od glavnih faktora rizika koji se prijavljuje u većini slučajeva novobolelih je pušenje. Od ostalih faktora rizika navode se profesionalna, kao i ekspozicija opšte populacije različitim hemikalijama, konzumiranje određenih namirnica, upotreba nekih lekova i dr. Buduća istraživanja trebalo bi da ispitaju kakvu ulogu imaju ovi faktori rizika kako bi se razumeli komplikovani mehanizmi karcinogeneze mokraćne bešike. Imajući u vidu da glavnu ulogu u karcinogenezi imaju sredinski faktori, logično je zaključiti da bi se promenom životnih navika i poboljšanjem radnih uslova smanjila incidenca oboljevanja od karcinoma bešike.

 

 

Ključne reči:

karcinom bešike, pušenje, profesionalna izloženost, prevencija; Polymorphisms

 

 

Abstract

 

Bladder cancer is common urinary system cancer and frequent cause of mortality and morbidity worldwide. It can appear in any age, but most frequent in older male patients. The highest incidences are reported in developed countries of Western Europe, North America and in Australia. As other malignancy, bladder cancer is result of interaction of genetic and environmental factors. Major risk factor among bladder cancer patients is smoking. Other risk factors reported are: occupational and environmental exposure to various chemicals, diet, specific drug therapy and other. Future research should examine the role of these factors in carcinogenesis of bladder cancer to understand its complicated mechanism. Having in mind, that environmental factors have major role in cancerogenesis, it seems logic to conclude that change of lifestyle and improve of working conditions would decrease incidence of bladder cancer.

 

 

Ključne reči:

bladder cancer, smoking, occupational exposure, prevention


 

 

References:

 

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PDF Antunović M. et al • MD-Medical Data 2018;10(2): 087-090

 

 

 

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