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ANALIZA AUTOPSIJSKIH DIJAGNOZA FETUSA, NOVOROĐENČADI I ODOJČADI OBDUKOVANIH U CENTRU ZA PATOLOGIJU I HISTOLOGIJU KLINIČKOG CENTRA VOJVODINE U PERIODU OD JUNA 2006. DO JUNA 2016. GODINE /
ANALYSIS OF DIAGNOSIS FROM FETAL, NEWBORN AND INFANT AUTOPSY PERFORMED IN A CENTRE FOR PATHOLOGY AND HISTOLOGY, CLINICAL CENTRE OF VOJVODINA DURING THE PERIOD JUNE 2006 - JUNE 2016.

Authors

 

Sandra Trivunić Dajko1,2, Tijana Javorić, Nada Vučković1,2, Matilda Đolai2,3, Milan Popović3

1Katedra za patologiju, Medicinski fakultet, Univerzitet u Novom Sadu
2Centar za patologiju i histologiju, Klinički centar Vojvodine, Novi Sad, Srbija
3Katedra za histologiju i embriologiju, Medicinski fakultet, Univerzitet u Novom Sadu

 

UDK: 616-091.5-053.2(497.113)


The paper was received 12.01.2018. Accepted: 17.02.2018

Rad primljen 12.01.2018. Rad prihvaćen: 17.02.2018.

 


Corresponding author/ Autor za korespodenciju:


doc. dr Sandra Trivunić Dajko
Katedra za patologiju, Medicinski fakultet, Univerzitet u Novom Sadu
Hajduk Veljkova 3, 21 000 Novi Sad
e-mail: sandra.trivunic-dajko@mf.uns.ac.rs

 

 

Sažetak

 

Uvod: Ključni ciljevi svake autopsije su indentifikacija uzroka smrti, objašnjenje patogenih mehanizama i kontrola kvaliteta kliničkih postupaka. Osnovni ciljevi fetalne ili perinatalne autopsije su nešto specifičniji i kompleksiniji, a sastoje se od utvrđivanja gestacijske starosti, stepena razvoja ploda, prisustva kongenitalnih anomalija, analize kliničkih dijagnoza i sprovedene terapije, kao i određivanja mogućih uzoka smrti i eventualnih rizika od ponovljene fetalne smrti.
Materija i metode: U retrospektivnoj, desetogodišnjoj studiji analizirane su autopsijske dijagnoze obdukovanih, demografski parametri, kao i uzroci smrti obdukovanih u Centru za patologiju i histologiju, Kliničkog centra Vojvodine. Od ukupno 2 283 obdukcije, u periodu od juna 2006. godine do juna 2016. godine, analizirani su najčešći uzroci smrti kod fetusa, novorođenčadi i odojčadi. Urađena je i analiza malformacija ploda, kao i prisustvo različitih sindroma. Prikazane su i najčešće kliničke indikacije artificijalnih abortusa, kao i korelacija između kliničkih i autopsijskih dijagnoza.
Rezultati: Najčešći uzrok smrti kod fetusa ostao je nepoznat i to u 85,3%, dok je kod odojčadi i novorođenčadi to periferna asfiksija, u 31% odnosno 42% obdukovanih slučajeva. Korelacija između kliničkih i autopsijskih dijagnoza postoji u 96% slučajeva. Najzastupljenije malformacije ploda su multiple malformacija u 46%, zatim slede malformacije CNS (24%) i gastrointestinalnog trakta sa udelom od 10%. Od ukupnog broja sindroma (182), kao najzastupljeniji izdvaja se Down-ov sindrom sa udelom od 65%.
Zaključak: U toku sprovođenja fetalne autopsije, treba se voditi predloženim protokolima, koje daju brojna inostrana udruženja patologa. Fetalne ili perinatalne obdukcija, kao i obdukcije generalno su često ogledalo stepena razvoja društva i njegovog ulaganja u zdravstveni sistem, odnosno društvene i epidemiološke situacije.

 

 

Ključne reči:

autopsije, uzrok smrti, fetus, novorođenče, odojče, sindromi

 

 

Abstract

 

Introduction: The main goals of every autopsy are identification of the cause of death, explanation of pathogenic mechanisms and quality control of clinical procedures. The basic aims of the fetal and perinatal autopsies are more specific and more complex, and include the determination of gestational age, maturity of the fetus, the presence of congenital anomalies, analysis of clinical diagnosis and performed therapy, as well as the determination of possible causes of death and potential risk of a fetal death. Material and methods: In this ten-year retrospective study, we analyzed autopsical diagnosis, demographic parameters, as well as the causes of death in autopsied patients in the Center of Pathology and Histology, Clinical Center of Vojvodina. Of the total 2 283 autopsied, in the time period from June 2006 to June 2016, we analyzed the most common causes of death of fetus, newborns and infants. Also, it was done analysis of malformations of the fetus, as the presence of various syndromes. The study also shows the most common clinical indication for artificial abortions, as well as the correlation between clinical and autopsical diagnosis. Results: The most common couse of fetal death remained unknown in 85.3%, while in infnts and newborns it was perinatal asphyxia in 31% and 42% of autopsied cases. Correlation between clinical and autopsy diagnosis was 96%. The most common malformations of the fetus are multiple malformations in 42%, followed by malformations of CNS (24%) and gastrointestinal tract with a share of 10%. Of the total number of syndromes the most common syndrome is Down's syndrome with a share of 65%. Conclusion: During fetal autopsy we should be guided with protocols suggested by numerous foreign pathologist associations. Fetal or perinatal autopsy, autopsy as generally, are often a mirror of society and development of their investments in the healthcare system, as well as mirror of the social and epidemiological situation.

 

 

Key words:

autopsies, cause of death, fetus, newborn, infant, syndrome

 

 

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PDF Trivunić Dajko S. et al • MD-Medical Data 2018;10(1): 039-044

 

 

 

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