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GENETSKI UZROCI INFERTILITETA KOD MUŠKARACA /
GENETIC CAUSES OF MALE INFERTILITY

Authors

 

Milan R. Obrenović1, Boris K. Privrodski2, Ivana I. Kavečan3, Jadranka D. Jovanović Privrodski3, Jasmina M. Mićanović4, Dušan P. Vuleta5, Helena D. Hrnjak Ilić6

1Kabinet za molekularnu genetiku, Institut za zdravstvenu zaštitu dece i omladine Vojvodine
2Klinika za dečiju hirurgiju, Institut za zdravstvenu zaštitu dece i omladine Vojvodine
3University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia
4Dom zdravlja, Sombor
5Klinički Centar Vojvodine, Novi Sad, Serbia
6Dom zdravlja, Temerin

 

UDK: 616.697:575


The paper was received 03.01.2018. Accepted: 03.02.2018.

Rad primljen: 03.01.2018. Rad prihvaćen: 03.02.2018.

 


Corresponding author/ Autor za korespodenciju:


Prof. dr Ivana Kavečan
Faculty of Medicine, University of Novi Sad
Hajduk Veljkova 3
21000 Novi Sad, Srbija
tel. 021 4880444
e-mail: ivana.kavecan@mf.uns.ac.rs

 

 

Sažetak

 

Sterilitet je u današnje vreme rastući problem. Genetski uzrok muškog steriliteta uključujući i hromozomske aberacije, mutacije gena i genetičke polimorfizme čini uzrok oko 10-15% slučajeva neplodnosti. Muškarci koji imaju hromozomske aberacije stvaraju spermatozoide sa aberantnim hromozomima u povećanom broju u odnosu na zdrave spermatozoide. Najčešći mogući genetski uzroci infertiliteta kod muškarca su: aneuploidije polnih hromozoma (Klinefelterov sindrom; sindrom dvostrukog Y hromozoma) i strukturne hromozomske aberacije (mikrodelecije Y hromozoma; translokacije i druge); mutacije gena i polimorfizam gena. Kako bi se mogla pružiti adekvatna genetska informacija supružnicima, značajna je detekcija genetskih faktora muškog infertiliteta pre samog postupka biomedicinski potpomognute oplodnje.

 

 

 

Ključne reči

muški infertilitet; kariotipizacija; hromozomske aberacije; mutacije; polimorfizam

 

 

Abstract

 

Infertility is a growing problem nowadays. The genetic cause of male infertility, including chromosomal aberrations, gene mutations and genetic polymorphisms are responsible for about 10-15% of infertility cases. Men who have chromosomal aberrations produce an increased number of spermatozoa with aberrations in comparison to healthy men. The most common possible genetic causes of infertility in a man are: chromosomal aberrations (Klinefelter syndrome, Double Y chromosome syndrome) and structural chromosomal aberrations (Y chromosomes microdeletions, translocations, and others); gene mutations and gene polymorphism. In order to provide adequate genetic information to spouses, detection of genetic factors of male infertility is important before process of biomedically assisted fertilization.

 

 

Key words:

Infertility, Male; Chromosome Aberrations; Karyotyping; Mutations; Polymorphisms

 

 

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PDF Obrenović R. M. et al • MD-Medical Data 2018;10(1): 011-016

 

 

 

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