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GINEKOMASTIJA KAO NEŽELJENO DEJSTVO MAPROTILINA – PRIKAZ SLUČAJA
GYNECOMASTIA AS ADVERSE EFFECT OF MAPROTILINE- CASE REPORT

Authors

 

Vladan Lukić1, Aleksandra Kovačević2, Nemanja Rančić2, Viktorija Dragojević-Simić2

1Nacionalni centar za kontrolu trovanja, Medicinski fakultet Vojnomedicinska akademija, Univerzitet odbrane, Beograd, Srbija / National Poison Control Center, Medical Faculty of the Military Medical Academy, University of Defence, Belgrade, Republic of Serbia
2Centar za kliničku farmakologiju, Medicinski fakultet Vojnomedicinska akademija, Univerzitet odbrane, Beograd, Srbija / Center for Clinical Pharmacology, Medical Faculty of the Military Medical Academy, University of Defence, Belgrade, Republic of Serbia

 


The paper was received on 06.04.2017. / Accepted on 10.04.2017

 


Correspondence to


Naučni saradnik dr sc. med. Nemanja Rančić;
Centar za kliničku farmakologiju,
Medicinski fakultet Vojnomedicinska akademija,
Univerzitet odbrane,
Beograd, Srbija; Crnotravska 17, 11002 Beograd, Srbija;
Tel.: +381638524443;
e-mail: : nece84@hotmail.com

 

 

Abstract

 

Background: Maprotiline is a tetracyclic antidepressant, therapeutically used for depressive disorders particularly if anxiety is associated with depression. It inhibits reuptake of biogenic amines, especially noradrenaline. Objective: This case report is related to gynecomastia as a probable maprotiline-related adverse effect, with almost no report in the available literature. Case report: A 72 years old man has been referred to clinical pharmacologist due to suspicion that pain and discomfort in both breasts, as well as gynecomastia diagnosed by physical and ultrasound examination are related with some of the prescribed drugs. After recommended maprotiline discontinuation, symptoms and signs of gynecomastia have been withdrawn. Conclusion: Gynecomastia can be manifested as a very rare adverse effect of maprotiline, even after irregular application of subtherapeutic doses of drug. This disorder is reversible and subsides soon after withdrawal of the drug.

 

 

 

Key words:

maprotiline, adverse effects, gynecomastia

 

 

Sažetak

 

Uvod: Maprotilin spada u grupu tetracikličnih antidepresiva, koji se danas prvenstveno koristi za lečenje bolesnika kod kojih je depresija udružena sa anksioznošću. Svoje dejstvo ostvaruje inhibicijom preuzimanja noradrenalina, dok je preuzimanje serotonina i dopamina slabije izraženo. Cilj: U radu je prikazan slučaj pojave ginekomastije kao verovatne neželjene reakcije na maprotilin, o čemu gotovo da nema podataka u dostupnoj literaturi. Prikaz slučaja: Muškarac, star 72 godine, se javio na pregled kod kliničkog farmakologa zbog sumnje da su pojava bolova i osećaj nelagodnosti u obe dojke, kao i fizikalnim i ultrazvučnim pregledom nađena ginekomastija povezani sa uzimanjem nekog od propisanih lekova. Nakon predloženog prestanka uzimanja maprotilina došlo je do povlačenja simptoma i znakova ginekomastije. Zaključak: Ginekomastija se može javiti kao veoma retka neželjena reakcija na anidepresiv maprotilin, čak i kod neredovne primene subterapijskih doza leka. Ova pojava je reverzibilna i povlači se vrlo brzo nakon obustave leka.

 

 

Ključne reči:

maprotilin, neželjena reakcija na lek, ginekomastija

 

 

References

 

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PDF Lukić V. et al. MD-Medical Data 2017;9(2): 127-131

 

 

 

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