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Народна библиотека Србије, Београд
61
MD : Medical Data : medicinska revija = medical review / glavni i odgovorni urednik Dušan Lalošević. - Vol. 1, no. 1 (2009)- . - Zemun : Udruženje za kulturu povezivanja Most Art Jugoslavija ; Novi Sad : Pasterovo društvo, 2009- (Beograd : Scripta Internacional). - 30 cm

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ISSN 1821-1585 = MD. Medical Data
COBISS.SR-ID 158558988


DEVELOPMENT OF HODGKIN LYMPHOMA IN THE ILEOCECAL REGION IN KIDNEY TRANSPLANT PATIENT ON LONG TERM IMMUNOSUPPRESSIVE THERAPY - A CASE REPORT
RAZVOJ HODŽKINOVOG LIMFOMA U ILEOCEKALNOJ REGIJI PACIJENTA SA TRANSPLANTIRANIM BUBREGOM NA DUGOROČNOJ IMUNOSUPRESIVNOJ TERAPIJI - PRIKAZ SLUČAJA

Authors

 

Vladimir Djordjević1, Aleksandra Buha2, Zeljko Radojković1, Nemanja Zarić1, Slavenko Ostojić1, Nebojša Lekić1, Aleksandar Ninić1, Milica Ćulafić3, Biljana Mihaljević 2, Darko Antić 2, Vojin Vuković2, Mirko Kerkez1
1 Clinic for Digestive Surgery, First Surgical Clinic, Clinical Center of Serbia, Belgrade, Serbia
2 Department of Toxicology "Akademik Danilo Soldatović", University of Belgrade-Faculty of Pharmacy, Belgrade, Serbia
3 Department of Pharmacokinetics and Clinical Pharmacy, University of Belgrade-Faculty of Pharmacy, Belgrade, Serbia
4 Clinic for Hematology, Clinical Center of Serbia, Belgrade, Serbia

 


 Rad je primljen 21.11.2016 Prihvaćen 25.11.2016.

 

 

Correspondence to:
Aleksandra Buha
Katedra za toksikologiju "Akademik Danilo Soldatović"
Univerzitet u Beogradu-Farmaceutski fakultet
Vojvode Stepe 450
11000 Beograd
Kontakt telefon: 063/377-687
e-mail: aleksandra@pharmacy.bg.ac.rs

 

 

Abstract

 

Following solid organ transplantation, the patient's management includes the provision of immunosuppressive therapy to the recipient. All kidney transplant recipients require life-long immunosuppression. Regardless the improving survival following solid organ transplantation, post-transplant complications such as the development of malignancy due to immunosuppression remain to be an issue. One of the most common malignancies encountered in the post–solid organ transplant is lymphoproliferative disorder likely developed as a consequence of immunosuppression. We report a case of plasma cell type lymphoma in the ileocecal region of a 45-year-old male kidney transplant patient who was on a tacrolimus-based regimen for ten years. Although literature data indicate differently localized lymphoma as an adverse reaction to the long term use of tacrolimus, to our knowledge, this is the first described case of lymphoma in the ileocecal region. Serious adverse drug reactions and potential toxicity of tacrolimus emphasize the importance of finding the optimal balance between effective drug concentration and the risk associated with its use.

 

Key words

adverse reaction; immunosuppressive therapy; malignancy; tacrolimus; toxicity

 

 

References

 

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UDK: 615.015-053.2
613.25-053.2
COBISS.SR-ID 226160396



PDF Đorđević V. et al •MD-Medical Data 2016;8(4): 265-268

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