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Katarina Baralić1, Milka Kostadinović1, Marko Antunović2, Snežana Đorđević2, Zorica Bulat1, Marijana Ćurčić1, Danijela Đukić-Ćosić1
1Katedra za toksikologiju "Akademik Danilo Soldatović", Univerzitet u Beogradu – Farmaceutski fakultet, Vojvode Stepe 450, 11221 Beograd, Srbija
2Centar za kontrolu trovanja, Vojnomedicinska akademija, Crnotravska 17, 11000 Beograd, Srbija


• Rad je primljen 20.06.2016. / Prihvaćen 01.07.2016.


Correspondence to:
Dr Danijela Đukić-Ćosić
Katedra za toksikologiju "Akademik Danilo Soldatović"
Univerzitet u Beogradu – Farmaceutski fakultet
Vojvode Stepe 450, 11221 Beograd
E mail:
telefon: 0638472709




This study presents the case of opiate analysis in urine of two female participants, aged between 20 and 25 who consumed commonly available bakery products with poppy seeds. One of the participants consumed strudel, the product with larger amount of poppy seeds, while the other consumed braid pastry. Urine samples of both participants (n=8) were collected 5, 12, 24, 30, 36, 48, 60 and 72 h after the consummation. Immunochromatographic screening test (cuttof 300 ng/mL) and LC-MS analysis were preformed on the presence of opiates.
The screening test for opiates was positive for a very long period of time, 48 h after the consumption of braid pastry and even 72 h after the consumption of strudel. LC-MS analysis verified the results of screening test and the presence of the main opioide alcaloides, morphine and codeine, was confirmed in all positive samples. Determined morphine level was higher than the level of codeine in all samples. The concentration of morphine (0.25 mg/L) was higher in urine of the participant who consumed strudel, compared to the concentration of morphine (0.06 mg/L) after the consumption of braid pastry.
The results of this research show that opiates can be found in urine after the consumption of products which contain poppy seed. Morphine and codeine can be detected even during the same time period as in the samples of users of psychoactive substances (3 days and longer). According to the results, retention time of opiates in urine is longer after the consumption of products with higher amounts of poppy. This finding should be taken into account in routine testing of employees in the workplace, members of the military, students in schools, as well as athletes.



Key words

opiates, products which contain poppy seed, urine, screening test, false positive results, LC-MS analysis





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UDK: 615.322:633.75-153.01
COBISS.SR-ID 226170124

PDF Baralić K. et al • MD-Medical Data 2016;8(3): 207-211

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