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PHARMACOKINETIC CONSIDERATIONS IN DRUG DOSING TO PEDIATRIC OBESE PATIENTS
FARMAKOKINETIČKA RAZMATRANJA U DOZIRANJU LEKOVA PEDIJATRIJSKIM GOJAZNIM PACIJENTIMA

Authors

 

Katarina Vučićević, Branislava Miljković, Milica Prostran
1 Department of Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy - University of Belgrade
2 Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine - University of Belgrade


 

• The paper was received on 12.07.2016./ Accepted on 20.07.2016.

 

 

Correspondence to:
assist. prof. Katarina Vučićević, PhD
Department of Pharmacokinetics and Clinical Pharmacy
Faculty of Pharmacy - University of Belgrade
VojvodeStepe 450. 11221 Belgrade, Serbia
phone: +381-11-3951-373
e-mail: kacav@pharmacy.bg.ac.rs

 

 

Abstract

 

Since the incidence of obesity continues to increase globally, this source of disposition variability remains a significant issue for clinicians. The prevalence of overweight and obesechildren has increased worldwide, causing substantial concern over proper therapeutic dosing in this population. Pharmacotherapy in these patients represents a major challenge in the clinical practice, because obese patients are, often excluded from the clinical trials. Consequently, data on drugs’ pharmacokinetics (PK) in this population of patients are scarce, incomplete and/or inconclusive. It is previously observed that different degrees of obesity may change the PK profile of drug. Consequently, there is a need for the descriptors of size of the organism that best describes the changes in the composition of the organism in obese patients, and the one that best predicts key PK parameters that define dosage regimen. Changes in PK parameters of certain drugs are clinically important in the obese children and adolescent patients, requiring changes inusual dosage regimen.

 

 

Key words

variability, children, body mass index

 

 

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PDF Vučićević K. et al • MD-Medical Data 2016;8(3): 149-153

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