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Dragana Aleksić1, Danilo Vojvodić2, Mirjana Antunović3, Vesna Putić4, Dušica Mirković5
1,3,4,5Sektor za farmaciju, Vojnomedicinska akademija, Beograd
2Institut za medicinska istraživanja, Vojnomedicinska akademija, Beograd


• The paper was received on 02.06.2016. / Accepted on 16.06.2016.


Correspodernce to:
dipl. farm. spec. Dragana Aleksić
Sektor za farmaciju, Vojnomedicinska akademija, Crnotravska 17,
 Antifašističke borbe 23 E, Beograd
tel. 011/3609-723, mob. tel. 064/14-26-623





The role of oxidative stress (OS) in the onset of various diseases has long been the subject of numerous studies and has been proven that oxidative stress play an active role in the development of AOM and subsequent tissue damage. Oxidative stress is associated with decrease in antioxidants or with increase in the production of oxidants. This leads to the peroxidation of phospholipids and causes damage in the vital substances of the body such as lipids, lipoproteins, proteins and DNA. At the end of the process, polyunsaturated fatty acids are hydrolysed into biologically active compounds and one of  the most important representative  is malondialdehid (MDA), which  reflects lipid peroxidation (LPO) in the body and is commonly used in analytical methods as its parameter. Normally the tissue damage caused by oxidants in the body is controlled by enzymatic and nonenzymatic antioxidant defense systems. The most important antioxidant enzymes are superoxide dismutase (SOD), glutathione reductase (GHPx), and catalase (CAT). Among non-enzymatic antioxidants are allocated glutathione (GSH), which is often used as an analytical parameter of oxidative stress, then tocopherol (vitamin E), ascorbic acid (vitamin C), carotene (vitamin A), urea and albumin AOM is  a significant cause of patient’s morbidity and cost to the health service. Recent advances  in the microbiology, genetics, drug delivery systems and further research of influence of lipid peroxidation status and nonenzymatic antioxidant capacity offer the potential for better treatments of AOM in the future.



Key words

acute otitis media, children, oxidative stress, parameters of oxidative stress





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PDF Aleksic D. et al • MD-Medical Data 2016;8(2) 105-108

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