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THE ROLE OF OXIDATIVE STRESS IN THE ONSET OF ACUTE OTITIS MEDIA IN CHILDREN
ULOGA OKSIDATIVNOG STRESA U NASTANKU AKUTNOG OTITIS MEDIJA KOD DECE

Authors

 

Dragana Aleksić1, Danilo Vojvodić2, Mirjana Antunović3, Vesna Putić4, Dušica Mirković5
1,3,4,5Sektor za farmaciju, Vojnomedicinska akademija, Beograd
2Institut za medicinska istraživanja, Vojnomedicinska akademija, Beograd


 

• The paper was received on 02.06.2016. / Accepted on 16.06.2016.

 

Correspodernce to:
dipl. farm. spec. Dragana Aleksić
Sektor za farmaciju, Vojnomedicinska akademija, Crnotravska 17,
 Antifašističke borbe 23 E, Beograd
tel. 011/3609-723, mob. tel. 064/14-26-623

e-mail: aleksicd13@gmail.com

 

Abstract

 

The role of oxidative stress (OS) in the onset of various diseases has long been the subject of numerous studies and has been proven that oxidative stress play an active role in the development of AOM and subsequent tissue damage. Oxidative stress is associated with decrease in antioxidants or with increase in the production of oxidants. This leads to the peroxidation of phospholipids and causes damage in the vital substances of the body such as lipids, lipoproteins, proteins and DNA. At the end of the process, polyunsaturated fatty acids are hydrolysed into biologically active compounds and one of  the most important representative  is malondialdehid (MDA), which  reflects lipid peroxidation (LPO) in the body and is commonly used in analytical methods as its parameter. Normally the tissue damage caused by oxidants in the body is controlled by enzymatic and nonenzymatic antioxidant defense systems. The most important antioxidant enzymes are superoxide dismutase (SOD), glutathione reductase (GHPx), and catalase (CAT). Among non-enzymatic antioxidants are allocated glutathione (GSH), which is often used as an analytical parameter of oxidative stress, then tocopherol (vitamin E), ascorbic acid (vitamin C), carotene (vitamin A), urea and albumin AOM is  a significant cause of patient’s morbidity and cost to the health service. Recent advances  in the microbiology, genetics, drug delivery systems and further research of influence of lipid peroxidation status and nonenzymatic antioxidant capacity offer the potential for better treatments of AOM in the future.

 

 

Key words

acute otitis media, children, oxidative stress, parameters of oxidative stress

 

 

References

 

  1. Qureishi A, Lee Y, Belfield K, Birchall JP, Daniel M. Update on otitis media-prevention and treatment.  Infection and Drug Resistance.  2014; 7: 15-24.
  2. Venekamp RP, Sanders S, Glasziou PP, Del Mar CB, Rovers MM. Antibiotics for acute otitis media in children [review]. Cochrane Database Syst Rev. 2013;1:CD000219.
  3. Klein JO. Epidemiology of otitis media. Pediatr Infect Dis J. 1989;8(Suppl 1):S9.
  4. Monasta L, Ronfani L, Marchetti F, et al. Burden of disease caused by otitis media: systematic review and global estimates. PLoS One. 2012;7(4):e36226.
  5. Renko M, Kristo A, Tapiainen T, et al. Nasopharyngeal dimensions in magnetic resonance imaging and the risk of acute otitis media. J Laryngol Otol. 2007;121(9):853–856.
  6. Cayé-Thomasen P, Hermansson A, Bakaletz L, et al. Panel 3: Recent advances in anatomy, pathology, and cell biology in relation to otitis media pathogenesis. Otolaryngol Head Neck Surg. 2013;148(Suppl 4): E37–E51
  7. Rovers MM, Schilder AG, Zielhuis GA, Rosenfeld RM. Otitis media. Lancet. 2004;363(9407):465–473.
  8. Murphy TF, Chonmaitree T, Barenkamp S, et al. Panel 5: Microbiology and immunology panel. Otolaryngol Head Neck Surg. 2013;148(Suppl 4):E64–E89.
  9. Miljanović O, Vojvodić D, Likić D, Magić Z. Sklonost ka akutnoj upali srednjeg uha kod dece – udruženost sa polimorfizmima gena. Med Data Rev 2009; 1(3): 37-40.
  10. Jovičić A, Jovanović M, Đorđević D, Dinčić E. Changes of oxidative and antioxidative activity in the patients with disseminated demyelinating disease of central nervous system. Vojnosanit. Pregl 1997; 54(3): 193-202.
  11. Đukić M, Jovanović M, Nedeljković M: Production of superoxide anion in alcoholics treated with disulfiram. Journal of the Neurological Sciences, 1997; 150(suppl):S266.
  12. Yariktas M, Doner F, Dogru H, Yasan H, Delibas N. The role of free oxygen radicals on the development of otitis media with effusion. Int J of Pediatric Otorhinolaringology. 2004; 68: 889-894
  13. Yilmaz T, Kocan EG, Besler HT, Yilmaz G, Gursel B. The role of oxidants and antioxidants in otitis media with effusion in children. Otolaryngol Head Neck Surg. 2004 Dec;131(6):797-803.
  14. Döner F, Delibas N, Dogru H, Yariktas M, Demirci M. The role of free oxygen radicals in experimental otitis media. J Basic Clin Physiol Pharmacol. 2002;13(1):33-40.
  15. Garça MF, Turan M, Avşar B, Kalkan F, Demir H et al. The evaluation of oxidative stress in the serum and tissue specimens of patients with chronic otitis media. Clinical and Experimental Otorhinolaryngology.  2015; Vol 8, 2: 97-101.
  16. Baysal E, Aksoy N, Kara F, Taysi S, Taskin A, Bilinc H, et al. Oxidative stress in chronic otitis media. Eur Arch Otorhinolaryngol. 2013 Mar; 270(4):1203-8.
  17. Garça MF, Aslan M, Tuna B, Kozan A, Cankaya H. Serum myeloperoxidase activity, total antioxidant capacity and nitric oxide levels in patients with chronic otitis media. J Membrane Biol 2013 Jun; 246:519-524.
  18. Aktan B, Taysi S, Gumustekin K, Bakan N, Sutbeyaz Y. Evaluation of oxidative stress in erithrocytes of guinea pigs  with experimental  otitis media and effusion. Ann Clin Lab Sci. 2003; 33(2):232-236.
  19. Karlidag T, Ilhan N, Kaygusuz I, keles E, Yalcin S. Comparasion of free radicals and antioxidant enzymes in chronic otitis media with and without tympanosclerosis. Laryngoscope 2004; 114(1):85-89.
  20. Garcia Callejo FJ, Ferrero EJ, Ventura AM, Cortes PS, Velert Vila MM. Lipoperoxidation in otorrhea of the middle ear as a marker of infection. Clinical application.  Acta Otorrinolaringol. Esp. 2000; 51:478—481.
  21. Kaygusuz I, Ilhan N, Karlidag T, Keles E, Yalcin S, Cetiner H. Free radicals and scavenging enzymes in chronic tonsillitis. Otolaryngol. Head Neck Surg. 2003; 129: 265—268.
  22. Cemek M, Ҫaksen H, Cemek F, Bayiroğlu F, Dede S  et al. Investigation of antioxidant status in children with acute otitis media and tonsillitis.  Int  J  Pediatr. Otorhinolaryngol. 2004; 68: 1381—1385.
  23. Cemek M, Dede S, Bayiroğlu F, Ҫaksen H, Cemek F, Yuca K. Oxidant and antioxidant levels in children with acute otitis media and tonsillitis: A comparative study. Int. J. Pediatr. Otorhinolaryngol. 2005; 69: 823-827.
  24. Yariktas M, Doner F, Dogru H, Yasan H, Delibas N. The role of free oxygen radicals on the development of otitis media with effusion. Int J of Pediatric Otorhinolaringology. 2004; 68: 889-894.

PDF Aleksic D. et al • MD-Medical Data 2016;8(2) 105-108

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