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Anđelija Živković Stanojević, Darko Simonović
Dom zdravlja Bela Palanka/Health Center Bela Palanka


• Rad je primljen 23.02.2016. Revidiran 10.03.2016. Prihvaćen 11.03.2016.





Thrombophilia is hereditary or acquired abnormality of the haemostasis' mechanism which could be a predisposition for thrombosis and therewith hypercoagulable states. Pregnancy is a hypercoagulable state which increases creation and levels of many factors of coagulation, but thrombophilia is risk factor that significantly enlarges number of  obstretic complications and also early miscarriages, and it continues in postpartum period for 6 weeks at least. This is a case outline of 35 years old woman who was tested for thrombophilia and sent to haematology examinations by her obstetrician after two early miscarriages. Haematology examinations confirmed hereditary thrombophilia: genetic mutations for MTHFR (heterozygous) and genetic mutations for PAI-1 4G/4G (homozygous) and also primary antiphospholipid syndrome. According to positive test for thrombophilia, it was reccomended for patient to use low molecular weight heparin (LMWH), aspirin, pronison and folic acid before another procedure of in vitro fertilisation (IVF) or in case of spontaneous pregnancy.
Aim: Showing the significance of thrombophilia as haemostasis' disorder which can increase risk for thrombosis, thromboembolic complications and whole series of obstetric complications including early miscarriages also.
Conclusion: It's important to recognize on time and to set apart risk groups of patients, especially women who are pregnant or planning pregnancy and send them to thrombophilia testings. The detection of this haemostasis' disorder and prophylactic and therapeutic measures could give the best chance for risk pregnancy keeping, its positive outcome and preventing maternal complications.



Key words

thrombophilia, pregnancy, thrombosis, obstetric complications, antiphospholipid syndrome, low molecular weight heparin.





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PDF Živković Stanojević A. and Simonović D. • MD-Medical Data 2016;8(1)

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