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MORFOLOŠKA PROCENA ZRELOSTI BUBREGA I GLOMERULSKIH TELAŠACA BUBREGA FETUSA /

MORPHOLOGICAL ASSESSMENT OF KIDNEY AND RENAL CORPUSCLE MATURITY

Authors

 

Milomir Bežanović1, Milana Bosanac 2, Natali Rakočević 3, Nemanja Gvozdenović4, Jelena Kesić5, Maja Samardžić Lukić1, Jelena Ilić Sabo 3, Jelena Amidžić3, Bojana Andrejić Višnjić3

1Institut za zdravstvenu zaštitu dece i omladine Vojvodine, Novi Sad
2Univerzitet u Novom Sadu, Medicinski fakultet
3Univerzitet u Novom Sadu, Medicinski fakultet, Katedra za histologiju i embriologiju
4Univerzitet u Novom Sadu, Medicinski fakultet, Katedra za urgentnu medicinu
5Univerzitet u Novom Sadu, Medicinski fakultet, Katedra za pedijatriju

 

UDK: 612.64:612.46


The paper was received / Rad primljen: 10.06.2021.

Accepted / Rad prihvaćen:25.06.2021.

 


Correspondence to:


Milana Bosanac
Medicinski fakultet Univerziteta u Novom Sadu,
Hajduk Veljkova 3, 21000 Novi Sad, Republika Srbija.
e-mail: 13782M15@mf.uns.ac.rs

 

 

Sažetak

 

 

Bubreg je nosilac brojnih funkcija u telu, a nastaje kao rezultat kompleksnog embrionalnog razvoja, a veruje se da se sazrevanje nastavlja i u prvim nedeljama života. Kod prevremeno rođene dece, nefrogeneza je pod uticajem drugačijih faktora i često se prerano zaustavlja, ostavljajući takve individua sa redukovanim brojem nefrona, što dugoročno može uticati na bubrežnu funkciju. U cilju sticanja uvida u zrelost bubrega i glomerularnih telašaca prevremeno rođene dece, ispitivanja se vrše na fetalnim bubrezima, ali metode procene nisu standardizovane i opšteprihvaćene, te je važno da se istaknu različite klasifikacije, kao i prednosti i mane pojedinih, u zavisnosti od perioda gestacije koji se proučava.

 

 

 

Ključne reči:

bubreg, fetus, morfologija, bubrežno telašce, nefron

 

 

 

Abstract

The kidney is the bearer of numerous functions in the body, and it arises as a result of complex embryonic development, and it is believed that maturation continues in the first weeks of life. In premature babies, nephrogenesis is influenced by other factors and often stops prematurely, leaving such individuals with a reduced number of nephrons, which can affect renal function in the long run. In order to gain insight into the maturity of the kidneys and glomerular bodies of premature babies, tests are performed on fetal kidneys, but assessment methods are not standardized and generally accepted, so it is important to point out different classifications and advantages and disadvantages of some, depending on gestational age which is being studied.

 

 

 


Keywords:

kidney, fetus, morphology, glomerular corpuscle, nephron

 

 

 

 

References:

  1. Guyton AC, Hall JE. Medicinska fiziologija. Jedanaesto izdanje. Beograd: Savremena administracija; 2008.
  2. Singh V. Textbook of Clinical Embryology. New Delhi: Reed Elsevier India Private Limited; 2012.
  3. Ryan D, Sutherland MR, Flores TJ, Kent AL, Dahlstrom JE, Puelles VG, et al. Development of the Human Fetal kidney from mid to late gestation in male and female infants. J Ebiom. 2018;27:275-83.
  4. Sutherland MR, Gubhaju L, Moore L, Kent AL, Dahlstrom JE, Horne RSC, et al. Accelerated maturation and abnormal morphology in the preterm neonatal kidney. J Am Soc Nephrol. 2011;22(7):1365-74.
  5. Sadler TW. Langman’s Medical Embryology. 13th ed. Philadelphia: Wolters Kluwer Health; 2015.
  6. Glassberg KI. Normal and abnormal development of the kidney: A clinician’s interpretation of current knowledge. J Urol. 2002;167(6):2339-51.
  7. Schell C, Wanner N, Huber TB. Glomerular development – shaping the multi-cellular filtration unit. Semin Cell Dev Biol. 2014;36:39-49.
  8. Ernst LM, Ruchelli ED, Huff DS, editors. Color Atlas of Fetal and Neonatal Histology. New York: Springer; 2011.
  9. Daković-Bjelaković M, Vlajković S, Čukuranović R, Antić S, Bjelaković G, Mitić D. Promena veličine glomerula tokom razvoja bubrega ljudskog fetusa. Srp Arh Celok Lek. 2006;134(1-2):33-7.
  10. Fonseca Ferraz ML,Dos Santos AM, Cavellani CL, Rossi RC, Corrêa RR, Dos Reis MA et al. Histochemical and immunohistochemical study of the glomerular development in human fetuses. Pediatr Nephrol. 2008;23(2):257-62.
  11. Minuth WW. Reading first coordinates from the nephrogenic zone in human fetal kidney. Nephron. 2018;138(2):137-146.
  12. Minuth WW. Key features of the nephrogenic zone in the fetal human kidney – hardly know but relevant for detection of the first traces impairing nephrogenesis. Cell Tissue Res. 2019;375(3):589-603.
  13. Naruse K, Fujieda M, Miyazaki E, Hayashi Y, Toi M, Fukui T, et al. An immunohistochemical study of developing glomeruli in human fetal kidneys. Kidney Int. 2000;57(5):1836-46.
  14. Takano K, Kawasaki Y, Imaizumi T, Matsuura H, Nozawa R, Tannji M, et al. Development of glomerular endothelial cells, podocytes and mesangial cells in the human fetus and infant. Tohoku J Exp Med. 2007;212(1):81-90.
  15. Macdonald M, Emery J. The late intrauterine and postnatal development of human renal glomeruli. J Anat. 1959;93(3):331-340.
  16. Thony HC, Luethy CM, Zimmermann A, Laux-End R, Oetliker OH, Bianchetti MG. Histological features of glomerular immaturity in infants and small children with normal or altered tubular function. Eur J Pediatr. 1995;154(9):S65-8.
  17. Puelles VG, Hoy WE, Hughson MD, Diouf B, Douglas-Denton RN, Bertram JF. Glomerular number and size variability and risk for kidney disease. Curr Opin Nephrol Hypertens. 2011;20(1):7-15.
  18. Otukesh H, Hoseini R, Rahimzadeh N, Hoseini S. Glomerular function in neonates. Iran J Kidney Dis. 2012;6(3):166-72.
  19. Schreuder MFBueters RRAllegaert K. The interplay between drugs and the kidney in premature neonates. Pediatr Nephrol. 2014;29(11):2083-91.

PDF07-MD-Vol 13 No 2 Jun 2021_Bezanovic et al.

 

 

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